Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

In the guinea pig Optimization test 1,6-Hexanediol Diglycidylether (HDDGE) at a concentration for challenge of 1% wt/v elicited positive dermal reactions in all 20 animals. In the mouse LLNA asay HDDGE had an Estimated Concentration 3 of 1.9% based on DPMs suggesting that HDDGE is a moderate dermal sensitizer. Based on the results of the mouse LLNA study and applying E.C.H.A. guidance (RIP Chapter 8) the Worker dermal DMEL/DNEL is estimated to be 22.6 ug/cm2.

Migrated from Short description of key information:
1,6-Hexanediol Diglycidylether (HDDGE) was accessed for dermal sensitizing potential in a guinea pig Optimization test and a O.E.C.D. Testing Guideline mouse LLNA assay conducted with GLP compliance. HDDGE gave a positive skin sensitizing response in both studies.

Respiratory sensitisation

Endpoint conclusion
Additional information:
Migrated from Short description of key information:
No data

Justification for classification or non-classification

The positive findings from both the guinea pig Optimization test and the mouse LLNA study are sufficient to support the Classification and Labeling of 1,6 -Hexanediol Diglycidylether (HDDGE) as R43, "May cause sensitization by skin contact".