Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

1,6-Hexanediol Diglycidylether (HDDGE) was evaluated for acute oral, dermal and inhalation toxicity by O.E.C.D. Testing Guideline studies conducted with GLP compliance.  HDDGE was relatively non-toxic by all routes.  

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
2 190 mg/kg bw

Additional information

1,6-Hexanediol Diglycidylether (HDDGE) has an acute oral LD50 in the range of 2190 - 3740 mg/kg of body weight based on the findings from three independent studies conducted with rats. The rat acute 4 hr inhalation LC50 was greater than 35 mg/m3 (~ 3.7 ppm). The concentration of 35 mg/m3 was the maximal vapor concentration achieved and no moralities were observed. The rat acute dermal LD50 was greater than 2000 mg/kg of body weight. No mortalites or adverse clincial signs were observed that this Limit Dose level. Therefore, generally, 1,6-Hexanediol Diglycidylether is not acutely toxic.

Justification for classification or non-classification

Based on findings from acute toxicity studies conducted by the oral, dermal; and inhalations routes of exposure, 1,6-Hexanediol Diglycidylether dose not require Classsification and Labeling for acute adverse effects.