Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 618-939-5 | CAS number: 933999-84-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In the guinea pig Optimization test 1,6-Hexanediol Diglycidylether (HDDGE) at a concentration for challenge of 1% wt/v elicited positive dermal reactions in all 20 animals. In the mouse LLNA asay HDDGE had an Estimated Concentration 3 of 1.9% based on DPMs suggesting that HDDGE is a moderate dermal sensitizer. Based on the results of the mouse LLNA study and applying E.C.H.A. guidance (RIP Chapter 8) the Worker dermal DMEL/DNEL is estimated to be 22.6 ug/cm2.
Migrated from Short description of key information:
1,6-Hexanediol Diglycidylether (HDDGE) was accessed for dermal sensitizing potential in a guinea pig Optimization test and a O.E.C.D. Testing Guideline mouse LLNA assay conducted with GLP compliance. HDDGE gave a positive skin sensitizing response in both studies.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
No data
Justification for classification or non-classification
The positive findings from both the guinea pig Optimization test and the mouse LLNA study are sufficient to support the Classification and Labeling of 1,6 -Hexanediol Diglycidylether (HDDGE) as R43, "May cause sensitization by skin contact".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
