Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 618-939-5 | CAS number: 933999-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Applying a weight-of-evidence approach 1,6-Hexanediol Diglycidylether (HDDGE) is not genotoxic. HDDGE was mutagenic only in the in vitro Ames/Salmonella gene mutation assay. When treatment was in vivo in rats and mice HDDGE induced no evidence of chromosome damage or repairable DNA damage.
Short description of key information:
1,6-Hexanediol Diglycidylether (HDDGE) was evaluated for genotoxic potential in the standard Ames/Salmonella gene-mutation assay and two in vivo tests. HDDGE was positive in the Ames/Salmonella mutation assay. However, HDDGE was negative for induction of chromosome damage in an oral mouse micronucleus test and an in vivo/in vitro rat hepatocyte UDS test.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Data is insufficient for the Classification and Labeling of 1,6-Hexanediol Diglycidylether (HDDGE) as a Mutagen based on negative findings in two in vivo test for genotoxicity.
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