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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

1,6-Hexanediol Diglycidylether was assessed for eye and skin irritation potential in rabbits following methods established by Draize.  Skin irritation was measured following a 24 hr occluded treatment.  Eye irritation was scored in both washed and unwashed rabbit eyes with the observation carried out to study day 14.    

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

1,6-Hexanediol Diglycidylether (HDDGE) induced a mean erythema score from three rabbits of 2.0 at 24 hr and 2.5 at 72 hr following a 24 hr occlusive treatment. This severe treatment conditions is not recommended by the current O.E.C.D. Testing Guideline for Skin Irritation/Corrosion. Repeated 24 hr occluded dermal exposure was found to be corrosive to rabbit skin in two independent studies. Based on the conjunctival irritation scores from 2 of 3 animals, HDDGE is a rabbit eye irritant. However, washing of the treated eye with physiological saline within 30 seconds of instillation prevented the irritational response.

Effects on skin irritation/corrosion: irritating

Effects on eye irritation: irritating

Justification for classification or non-classification

Based on the findings from an outdated skin irritation study conducted on rabbits with the severe exposure conditions of a 24 hr occluded tretment, 1,6-Hexanediol Diglycidylether is a skin irritant. The results of a rabbit eye irritation study demonstrate that 1,6-Hexanediol Diglycidylether is also an eye irritant.