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EC number: 618-939-5 | CAS number: 933999-84-9
- Life Cycle description
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
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- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Terrestrial toxicity
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-({[6-({1-chloro-3-[(oxiran-2-yl)methoxy]propan-2-yl}oxy)hexyl]oxy}methyl)oxirane; 2-[({6-[(oxiran-2-yl)methoxy]hexyl}oxy)methyl]oxirane; 3-chloro-2-({6-[(oxiran-2-yl)methoxy]hexyl}oxy)propan-1-ol; 6-[(oxiran-2-yl)methoxy]hexan-1-ol
- EC Number:
- 618-939-5
- Cas Number:
- 933999-84-9
- Molecular formula:
- C6H14O2 + C3H5ClO
- IUPAC Name:
- 2-({[6-({1-chloro-3-[(oxiran-2-yl)methoxy]propan-2-yl}oxy)hexyl]oxy}methyl)oxirane; 2-[({6-[(oxiran-2-yl)methoxy]hexyl}oxy)methyl]oxirane; 3-chloro-2-({6-[(oxiran-2-yl)methoxy]hexyl}oxy)propan-1-ol; 6-[(oxiran-2-yl)methoxy]hexan-1-ol
- Details on test material:
- As per IUCLID5 Sections 1.1. - 1.4.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- White rabbits bred and raised at Kleintierfarm Madörin AG, CH-4414 Füllinsdorf, weighing 2 to 3 kgs. The animals were housed individually in metal cages, numbered by ear tags, were kept at a constant room temperature of 22 + 2°C, at a relative humidity of 55 + 10 % and on a 12 hour light cycle day. The animals had ad libitum access to standard rabbit feed - NAFAG, No. 814, Gossau SG - and water. Prior to treatment they were adapted to the laboratories for a minimum of 4 days. Only rabbits with normal ophthalmic findings were used for these tests.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- 14 d
- Observation period (in vivo):
- 14 d
- Number of animals or in vitro replicates:
- 3 male, 3 female
- Details on study design:
- Approximately 0.1 mL of 1,6-Hexanediol Diglycidylether (HDDGE) was instilld into the conjuntival sac of the left eye of each rabbit. In half of the animals following approximately 30 seconds of treatment, the treated eye was flushed with 10 mL of physiological saline (washed). Eye irritation was scored with the aid of a slit lamp on study days: 1, 2, 3, 4, 7, 10 and 14 following method of Draize.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 18.4
- Reversibility:
- fully reversible
- Remarks on result:
- other: unrinsed eyes
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 3.3
- Reversibility:
- fully reversible
- Remarks on result:
- other: rinsed eyes
- Irritant / corrosive response data:
- Maximal levels of irritation were observed in the cornea, iris and conjunctiva 24 to 72 hr after treatment. Irritation of the cornea and iris was fully recovered by study day 4. Conjuntival irritation had recovered by study day 10. In the washed rabbit eyes no irritation of the cornea or iris was observed. The washed eye conjunctiva had fully recovered by study day 7.
Any other information on results incl. tables
In the unrinsed eyes, a reversible irritation of the cornea was observed after 24-72 hours. A reversible irritation of the iris was observed after 24 and 48 hours. The irritation of the conjunctiva was strongest after 24 hours and decreased to a negligible level after 14 days. The highest irritation score was 29.7 and was observed after 24 hours. In the rinsed eyes, no irritation of cornea and iris was observed at any reading. Irritation was seen only in the conjunctiva with a maximum mean score of 3.3 after 48 hours. After 7 days all irritation had disappeared.
Time after exposure hours
|
MEAN REACTION SCORE |
|||||
Unrinsed eyes (A) |
Rinsed eyes (B) |
|||||
cornea |
iris |
conjunctiva |
cornea |
iris |
conjunctiva |
|
1 2 3 4 7 10 14 |
16.7 11.7 6.7 0 0 0 0 |
1.7 1.7 0 0 0 0 0 |
0 0 0 0 0 0 0 |
0 0 0 0 0 0 0 |
0 0 0 0 0 0 0 |
2 3.3 1.3 1.3 0 0 0 |
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Based on conjunctival irritation scores, 1,6-Hexanediol Diglycidylether is a rabbit eye irritant for Classification and Labeling purposes. However, washing of treated eyes with physiological saline prevented significant irritation.
- Executive summary:
1,6-Hexanediol Diglycidylether (HDDGE) was accessed for the potential to be a rabbit eye irritant ia a Draize method study. Three of the six aninmals had their treated eye washed with physiological saline approximately 30 seconds following the initiation of treatment. Based on conjunctival irritation scores, 1,6-Hexanediol Diglycidylether is a rabbit eye irritant for Classification and Labeling purposes. However, washing of treated eyes with physiological saline prevented significant irritation.
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