Registration Dossier
Registration Dossier
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EC number: 232-391-0 | CAS number: 8013-07-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
A 72 hour growth inhibition toxicity study was performed according to the 87/302/EEC page 89-94 Algal Inhibition Test guideline. Scenedesmus subspicatus was exposed for 72hours to nominal concentrations of TK 11278. Based on the initial measured exposure concentrations the 72 hour EbC50 was calculated to be 8 mg/L (with 95% confidence limits of 5.4 to 11.6 mg/L), the corresponding no-observed effect concentration (NOEC) was 0.7 mg/L.
Key value for chemical safety assessment
Additional information
A 72 hour growth inhibition toxicity study was performed according to the 87/302/EEC page 89-94 Algal Inhibition Test guideline. Scenedesmus subspicatus was exposed for 72hours to nominal concentrations of TK 11278. Based on the initial measured exposure concentrations the 72 hour EbC50was calculated to be 8 mg/L (with 95% confidence limits of 5.4 to 11.6 mg/L), the corresponding no-observed effect concentration (NOEC) was 0.7 mg/L (Grade, 1993).
The water solubility of ESBO is estimated to be <0.02 µg/L, categorised as insoluble REACH, see section 4.8 for details. Ideally aquatic toxicity studies should not be conducted above the limit of water solubility, the study reported here tested nominal concentrations up to 100 mg/L. According to Annex VII a growth inhibition study with algae is required unless there are mitigating factors such as the test substance is insoluble, this is the case for ESBO. Therefore, the algae study is reported here for information only (this study was also reported in the OECD SIDS Initial Assessment Report for SIAM 22, 18 -21 April 2006), the endpoint will not be used for PNEC setting or in any risk assessment.
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