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Water solubility

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Description of key information

A Saferpharm study showed that the water solubility of Epoxidised Soybean oil was less than 1.36 x 10-3 g/l of solution at 20.0 +/- 0.5°C.
However, the ESBO found in solution during the water solubility study represented only the lower molecular weight range of the test material components. . Calculations of water solubilities using Advanced Chemistry (ACD/Labs) Software V9.04 ((C) 1994 -2010 ACD/Labs) showed that solubility of ESBO is estimated to be < 0.02 µg/L, and thererefore,it was concluded that ESBO is "highly insoluble".
The WAF solubility of EODA is < 0.05 mg/L as reported in the OECD SIDS 2006 for epoxidised oils and derivatives.

Key value for chemical safety assessment

Water solubility:
0.02 µg/L
at the temperature of:
20 °C

Additional information

A Saferpharm study showed that the water solubility of Epoxidised Soybean oil was less than 1.36 x 10-3 g/l of solution at 20.0 +/- 0.5°C.

However, the ESBO found in solution during the water solubility study represented only the lower molecular weight range of the test material components.

Calculations of water solubilities using Advanced Chemistry (ACD/Labs) Software V9.04 ((C) 1994 -2010 ACD/Labs) showed that solubility of ESBO is estimated to be < 0.02 µg/L, and thererefore,it was concluded that ESBO is "highly insoluble".

The OECD SIDS 2006 report explains that the nature of epoxidised oil derivatives to form an emulsion upon mixing in water. They do not dissolve and they do not remain as individual molecules in solution, which reflects the difficulty with which the undissolved microemulsion is separated from true aqueous solution. This was confirmed in the attempts to prepare appropriate water accommodated fractions (WAF) of EODA (CAS number 68609-92-7), which did not contain dissolved test substance at or above the method detection limit of 0.05 mg/L. These results from the WAF preparation suggest that actual water solubility of the EOD substances are lower than the values reported. The WAF solubility of EODA is < 0.05 mg/L.

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