Registration Dossier
Registration Dossier
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EC number: 220-688-8 | CAS number: 2867-47-2
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary source available.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Morphological changes of rabbit skin by application of Dentine Primer
- Author:
- Manabe A et al.
- Year:
- 1 990
- Bibliographic source:
- Dent. Mater. J., 9 (2), 147-152
- Reference Type:
- secondary source
- Title:
- Manabe. A. et al., Morphological changes of rabbit skin by application of Dentine Primer, Dent. Mater. J., 9 (2), 147-152, 1990
- Author:
- Manabe A. et al.
- Year:
- 2 003
- Bibliographic source:
- cited in: OECD SIDS, 2-Dimethylaminoethylmethacrylate, CAS No: 2867-47-2, 07/2003
Materials and methods
- Principles of method if other than guideline:
- Subacute dermal toxicity study in rabbits. Twice per day 50 µl of undiluted test substance were applied to the sheared rabbit skin for 7 days, followed by a 7-day post-exposure period.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-dimethylaminoethyl methacrylate
- EC Number:
- 220-688-8
- EC Name:
- 2-dimethylaminoethyl methacrylate
- Cas Number:
- 2867-47-2
- Molecular formula:
- C8H15NO2
- IUPAC Name:
- 2-(dimethylamino)ethyl methacrylate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- TEST SITE
- Area of exposure: sheared skin
TEST MATERIAL
- Amount applied: 30 µl - Duration of treatment / exposure:
- 7 days
- Frequency of treatment:
- twice per day
- Control animals:
- yes
- Details on study design:
- - Post-exposure recovery period: 7 days
Results and discussion
Results of examinations
- Details on results:
- Important morphological change (coagulation, necrosis, oedema and little cell infiltration) of the dermis. High irritation due to 2-propenoic acid, 2-methyl, dimethylaminoethylester is not reversible 7 days after the end of treatment. Systemic effects were not reported.
Effect levels
- Dose descriptor:
- NOAEL
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
