2-dimethylaminoethyl methacrylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Remarks:

Original report is only available in Japanese. The translation is in progress. Therefore, the report is cited by a peer-reviewed OECD SIDS.

Data source

Reference

Reference 1

Reference Type:

other: summary report

Title:

Unnamed

Year:

1998

Reference 2

Reference Type:

publication

Title:

Toxicity Testing Reports of Envirmnmental Chemicals vol. 6, p. 539-568

Author:

Ministry of Health and Welfare, Japan

Year:

2003

Bibliographic source:

cited in: OECD SIDS, 2-Dimethylaminoethylmethacrylate, CAS No: 2867-47-2, 07/2003

Materials and methods

Test guideline

Qualifier:

according to

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Test material

Reference

Name:

Unnamed

Type:

Constituent

Test material form:

liquid

Specific details on test material used for the study:

TEST MATERIAL:
Name of test material: 2-(dimethylamino)ethyl methacrylate

Test animals

Species:

rat

Strain:

other: Crj:CD(SD)

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Doses:

0 (Vehicle), 500, 1000, 2000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

not determinable due to absence of adverse toxic effects

Mortality:

No deaths occurred in any of the treated groups.

Gross pathology:

At necropsy, raised patches in the forestomach were observed in males of the 2000 mg/kg group.

Other findings:

Histopathologically, papillomatous hyperplasia in the forestomach was apparent.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Executive summary:

A single oral toxicity study revealed a LD50 value of above 2000 mg/kg bw for the substance in both sexes.