Registration Dossier
Registration Dossier
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EC number: 283-294-5 | CAS number: 84604-16-0 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Saccharomyces cerevisiae, Saccharomycelaceae.
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- other: Expert statement
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Determination of the partition coeffecient for the yeast Saccharomyces Cerevisiae is not scientifically feasible.
Data source
Reference
- Reference Type:
- other:
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Guideline:
- other: The experimental log Kow determination is technically not feasible. The main reasons are developed in the attached report concerning each available method (AU A.8, OECD 107), (EU A.8, OECD 117), and (OECD 123).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Saccharomyces cerevisiae, ext.
- EC Number:
- 283-294-5
- EC Name:
- Saccharomyces cerevisiae, ext.
- Cas Number:
- 84604-16-0
- Molecular formula:
- Not applicable as the substance is an UVCB
- IUPAC Name:
- Yeast extract, Saccharomyces cerevisiae
- Details on test material:
- - Name of test material (as cited in study report): Saccharomyces cerevisiae, Extract (Springer 0204/0-LQ-L)
- Molecular formula: -
- Molecular weight: -
- Substance type: Brown liquid
- Physical state: liquid
- Analytical purity: 48.0 – 52.0% (dry matter)
- Impurities (identity and concentrations): -
- Composition of test material, percentage of components: -
- Isomers composition: -
- Purity test date: -
- Lot/batch No.: 081000310
- Expiration date of the lot/batch: 30 April 2012
- Stability under test conditions: Stable
- Storage condition of test material: At room temperature in the dark
- Other: -
Constituent 1
Study design
- Analytical method:
- not specified
- other: Statement supporting that the partition coefficient test for the yeast extract is scientifically not feasible
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 0
- Temp.:
- 0 °C
- pH:
- 0
- Remarks on result:
- not measured/tested
- Details on results:
- Due to the complex composition of the substance “Saccharomyces cerevisiae extract”, it is not feasible to determine its partition coefficient experimentally. The shake flask method, the HPLC method and the slowstirring method are not applicable to this substance. QSARs calculations are not possible due to the complex composition and the unknown precise structure of the constituents. Even the estimation of log Kow based on the solubility in water and in n-octanol is technically not feasible. A rough estimated single log Kow value or a broad range of log Kow values for “Saccharomyces cerevisiae extract” would not contribute to hazard assessment or to classification. Indeed, the constituents of this soluble fraction are very different substances with different physical-chemical properties and probably the log Kow value of the organic constituents will cover a broad range of log Kow values. However due to the high solubility of these components (20% at 50°C pH 5 to 5.5), the log Kow must be low, and therefore it is concluded that there is no concern on bioaccumulation.
Any other information on results incl. tables
The test substance is a complex mixture of organic components in water. Each component will have its own partition coefficient. Therefore the partition coefficient of the test substance cannot be determined.
Applicant's summary and conclusion
- Conclusions:
- Due to the complex composition of the substance “Saccharomyces cerevisiae extract”, it is not feasible to determine its partition coefficient experimentally.
- Executive summary:
Due to the complex composition of the substance “Saccharomyces cerevisiae extract”, it is not feasible to determine its partition coefficient experimentally. The shake flask method, the HPLC method and the slowstirring method are not applicable to this substance. QSARs calculations are not possible due to the complex composition and the unknown precise structure of the constituents. Even the estimation of log Kow based on the solubility in water and in n-octanol is technically not feasible. A rough estimated single log Kow value or a broad range of log Kow values for “Saccharomyces cerevisiae extract” would not contribute to hazard assessment or to classification. Indeed, the constituents of this soluble fraction are very different substances with different physical-chemical properties and probably the log Kow value of the organic constituents will cover a broad range of log Kow values. However due to the high solubility of these components (20% at 50°C pH 5 to 5.5), the log Kow must be low, and therefore it is concluded that there is no concern on bioaccumulation.
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