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EC number: 283-294-5 | CAS number: 84604-16-0 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Saccharomyces cerevisiae, Saccharomycelaceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- other: Expert statement
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Determination of the partition coeffecient for the yeast Saccharomyces Cerevisiae is not scientifically feasible.
Data source
Reference
- Reference Type:
- other:
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Guideline:
- other: The experimental log Kow determination is technically not feasible. The main reasons are developed in the attached report concerning each available method (AU A.8, OECD 107), (EU A.8, OECD 117), and (OECD 123).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Saccharomyces cerevisiae, ext.
- EC Number:
- 283-294-5
- EC Name:
- Saccharomyces cerevisiae, ext.
- Cas Number:
- 84604-16-0
- Molecular formula:
- Not applicable as the substance is an UVCB
- IUPAC Name:
- Yeast extract, Saccharomyces cerevisiae
- Details on test material:
- - Name of test material (as cited in study report): Saccharomyces cerevisiae, Extract (Springer 0204/0-LQ-L)
- Molecular formula: -
- Molecular weight: -
- Substance type: Brown liquid
- Physical state: liquid
- Analytical purity: 48.0 – 52.0% (dry matter)
- Impurities (identity and concentrations): -
- Composition of test material, percentage of components: -
- Isomers composition: -
- Purity test date: -
- Lot/batch No.: 081000310
- Expiration date of the lot/batch: 30 April 2012
- Stability under test conditions: Stable
- Storage condition of test material: At room temperature in the dark
- Other: -
Constituent 1
Study design
- Analytical method:
- not specified
- other: Statement supporting that the partition coefficient test for the yeast extract is scientifically not feasible
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 0
- Temp.:
- 0 °C
- pH:
- 0
- Remarks on result:
- not measured/tested
- Details on results:
- Due to the complex composition of the substance “Saccharomyces cerevisiae extract”, it is not feasible to determine its partition coefficient experimentally. The shake flask method, the HPLC method and the slowstirring method are not applicable to this substance. QSARs calculations are not possible due to the complex composition and the unknown precise structure of the constituents. Even the estimation of log Kow based on the solubility in water and in n-octanol is technically not feasible. A rough estimated single log Kow value or a broad range of log Kow values for “Saccharomyces cerevisiae extract” would not contribute to hazard assessment or to classification. Indeed, the constituents of this soluble fraction are very different substances with different physical-chemical properties and probably the log Kow value of the organic constituents will cover a broad range of log Kow values. However due to the high solubility of these components (20% at 50°C pH 5 to 5.5), the log Kow must be low, and therefore it is concluded that there is no concern on bioaccumulation.
Any other information on results incl. tables
The test substance is a complex mixture of organic components in water. Each component will have its own partition coefficient. Therefore the partition coefficient of the test substance cannot be determined.
Applicant's summary and conclusion
- Conclusions:
- Due to the complex composition of the substance “Saccharomyces cerevisiae extract”, it is not feasible to determine its partition coefficient experimentally.
- Executive summary:
Due to the complex composition of the substance “Saccharomyces cerevisiae extract”, it is not feasible to determine its partition coefficient experimentally. The shake flask method, the HPLC method and the slowstirring method are not applicable to this substance. QSARs calculations are not possible due to the complex composition and the unknown precise structure of the constituents. Even the estimation of log Kow based on the solubility in water and in n-octanol is technically not feasible. A rough estimated single log Kow value or a broad range of log Kow values for “Saccharomyces cerevisiae extract” would not contribute to hazard assessment or to classification. Indeed, the constituents of this soluble fraction are very different substances with different physical-chemical properties and probably the log Kow value of the organic constituents will cover a broad range of log Kow values. However due to the high solubility of these components (20% at 50°C pH 5 to 5.5), the log Kow must be low, and therefore it is concluded that there is no concern on bioaccumulation.
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