Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

acute toxicity: inhalation
Type of information:
other: Review
Adequacy of study:
weight of evidence
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference Type:
review article or handbook

Materials and methods

Test guideline
no guideline required
other: Not applicable
Principles of method if other than guideline:
Not applicable
GLP compliance:

Test material

Constituent 1
Reference substance name:
Saccharomyces cerevisiae, ext.
EC Number:
EC Name:
Saccharomyces cerevisiae, ext.
Cas Number:
Molecular formula:
Not applicable as the substance is an UVCB
Yeast extract, Saccharomyces cerevisiae
Test material form:
solid: particulate/powder
migrated information: powder
Details on test material:
Name of test material (as cited in study report): Yeast extract (SPRINGER 0251 / 0-MG-L)
- Substance type: Powder
- Physical state: light brown powder
- Analytical purity: Not indicated by the sponsor; treated as 100% pure
- Lot/batch No.: 071403960
- Expiration date of the lot/batch: 31 August 2017
- Stability under storage conditions: stable
- Storage condition of test material: At room temperature
- Solubility in water: very soluble (> 10000 mg/L) at 50°C and pH 5 to 5.5

Results and discussion

Effect levels
Key result
not specified
Dose descriptor:
other: Not applicable
Effect level:
0 other: Not applicable
Based on:
not specified
Remarks on result:
other: Review does not refer to the quantities.

Applicant's summary and conclusion

Particles with an aerodynamic diameter > 10 µm are very unlikely to reach the gas-exchange region of the lung.
Executive summary:

In occupational hygiene, particle size is usually described in terms of the aerodynamic diameter, which is a measure of the particle’s aerodynamic properties. Whether or not an airborne particle is inhaled depends on its aerodynamic diameter, the velocity of the surrounding air, and the persons’ breathing rate. How particles then proceed through the respiratory tract to the different regions of the lungs, and where they are likely to deposit, depend on the particle aerodynamic diameter, the airway dimensions and the breathing pattern.