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EC number: 283-294-5
CAS number: 84604-16-0
Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Saccharomyces cerevisiae, Saccharomycelaceae.
Three acute oral toxicity studies are available (two with mice and one with rat) of which two were performed according to OECD guidelines and in compliance with GLP. An acute dermal toxicity study was available performed according to OECD guidelines and in compliance with GLP.
Three acute oral toxicity studies are available (two with mice and one
with rat). The studies with mice on Maxarome and Gistex are performed
according to internationally accepted testing guidelines and in
accordance with GLP. Maxarome and Gistex have a comparable
macro-composition based on dry matter and salt free dry matter and
therefore the study results can be used for Saccharomyces cerevisiae,
ext. Both tests showed no mortality and the LD50 derived was > 2000
The study with rats is not according to any internationally recognized
guideline and before GLP and is performed with Gistex. This study could
be used as supportive evidence.
Furthermore, an acute dermal toxicity study with rats was performed
according to OECD and in compliance with GLP. Saccharomyces cerevisiae,
ext. was used as test material in this study. No mortality was seen in
this study and therefore the LD50 was determined to be >2000 mg/kg bw.
In absence of any mortality in studies with mice and rats (oral
performed on surrogates and dermal route), Saccharomyces cerevisiae,
ext. does not need to be classified according to DSD or CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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