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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was conducted in 1959. It is not a guideline study and is non-GLP.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1959
Report date:
1959

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The test material prepared as a suspension in peanut oil was placed in contact with intact abdominal skin of rabbits for 6 hours
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
2,6-di-tert-butylphenol
EC Number:
204-884-0
EC Name:
2,6-di-tert-butylphenol
Cas Number:
128-39-2
Molecular formula:
C14H22O
IUPAC Name:
2,6-di-tert-butylphenol
Test material form:
solid: crystalline

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Rats were exposed for 7h to varying amounts of test substance (AN-33) 3.2 to 10 ml per kg.
Duration of exposure:
7 hours
Doses:
3.2 to 10 ml per kg
No. of animals per sex per dose:
No data
Control animals:
no
Details on study design:
No details

Results and discussion

Preliminary study:
The rats had no local injuries and showed no signs of systemic illness following dermal exposure.
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD0
Effect level:
10 mL/kg bw
Based on:
other: technical containing 70-80% 2,6-di-tert-butylphenol
Mortality:
None
Clinical signs:
other: No data
Gross pathology:
No data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Not classified for dermal toxicity.