Registration Dossier
Registration Dossier
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EC number: 246-466-0 | CAS number: 24800-44-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study predates OECD guidelines and GLP, not performed in accordance with modern guideline standards, but contributing to overall assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- 0.01 ml of undiluted tripropylene glycol was applied to clipped uncovered intact skin of 5 rabbit bellies. Results were scored after 24 hours using a 10 grades system (no injury from undiluted substance = grade 1).
- GLP compliance:
- no
Test material
- Reference substance name:
- [(methylethylene)bis(oxy)]dipropanol
- EC Number:
- 246-466-0
- EC Name:
- [(methylethylene)bis(oxy)]dipropanol
- Cas Number:
- 24800-44-0
- Molecular formula:
- C9H20O4
- IUPAC Name:
- 1,1'-[propane-1,2-diylbis(oxy)]dipropan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Tripropylene glycol
- Substance type: organic
- Analytical purity: not specified
- Lot/batch No.: 06827
- Identification: S-145541
- CHF sample No: 37-61
- Date of receipt: 2-8-74
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- The nonfasted animals were maintained on appropriate Rockland diets and water ad libitum except during period of manipulation or confinement.
Test system
- Type of coverage:
- open
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.01 ml
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- 5
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Remarks:
- Study duration was only 24 hours.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Remarks:
- Study duration was 24 hours.
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 10
- Reversibility:
- no data
- Remarks on result:
- other: Study only conducted for 24 hours
- Irritant / corrosive response data:
- No irritation was observed in 1 animals; moderate capillary injection was observed on 4 rabbits. The overal irritation score was 2 out of 10 (1 = no irritation from undiluted substance).
Applicant's summary and conclusion
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