Registration Dossier

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
20 mg/L
Assessment factor:
50
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
10 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
2 mg/L
Assessment factor:
500
Extrapolation method:
assessment factor

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
500 mg/L
Assessment factor:
100
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
48.1 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
4.81 mg/kg sediment dw

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
5.3 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Based on a combination of test data tripropylene glycol presents a low hazard concern for the aquatic environment.

One non-GLP compliant guideline study (OECD 203) is available for tripropylene glycol. The 96-h LC50 value is >1,000 mg/l (nominal concentration) in Oryzias latipes in a semi-static test. One non-GLP compliant guideline study (OECD 202) is available for tripropylene glycol. The 24-h EC50 value is > 1,000 mg/l (nominal concentration) in Daphnia magna in a static test. One non-GLP compliant guideline study (OECD 202) is available for tripropylene glycol. The 21-d NOEC value is >1,000 mg/l (nominal concentration) in Daphnia magna in a semi-static test. One non-GLP compliant guideline study (OECD 201) is available for tripropylene glycol. The 72-h EbC50 value and 72-h NOEbC value is >1,000 mg/l (nominal concentration) in Pseudokirchnerella subcapitata (reported as Selenastrum capricornutum) (OECD, 1994).

A GLP compliant guideline ISO 8192 (Test for Inhibition of Oxygen Consumption by Activated Sludge) study is available for tripropylene glycol. The 24-h EC50 is >50,000 mg/l in activated sludge (Bayer, 1990).

Although chronic test data for fish are not available, long-term testing in Daphnia suggest that tripropylene glycol will not cause chronic toxicity to aquatic organisms. Additional testing seems therefore not be necessary.

Conclusion on classification

Initial EU and GHS Hazard hazard classification of Tripropylene Glycol

 

According to Directive 67/548/EEC, results of validated structure activity relationships and expert judgment may also be taken into account where appropriate with regard to classification and labelling of substances.

The lowest acute aquatic toxicity value is >1000 mg/l for the fish species Oryzias latipes, for the invertebrate species Daphnia magnaand for the algae species Pseudokirchnerella subcapitata (reported as Selenastrum capricornutum).

Based on the result of the octanol/water partition coefficient (Log Kow = -0.379) tripropylene glycol is not expected to significantly accumulate in aquatic organisms. Furthermore, the substance is found readily biodegradable. For these reasons, tripropylene glycol is not classified in Annex I of Directive 67/548/EEC and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.