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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study conducted in accordance with OECD guideline 401 and GLP by MHW Japan. The original report was requested, but could not be recovered, only the abstract in English was received. However, the study was considered acceptable by OECD SIDS.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Purity > 98%

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Doses:
500, 1000 and 2000 mg/kg bw
No. of animals per sex per dose:
5/sex/dose

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
There were no mortalities.
Clinical signs:
No abnormal clinical signs were observed.
Body weight:
Body weight changes of each treated group were virtually the same as those of the control group.
Gross pathology:
No remarkable changes were found in any of the animals necropsied.

Applicant's summary and conclusion