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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study predates OECD guidelines and GLP, minor restrictions in design and reporting, but otherwise adequate for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report Date:
1974

Materials and methods

Principles of method if other than guideline:
Rats were exposed to saturated vapor of tripropylene glycol generated at room temperature for 8 h.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Tripropylene glycol
- Substance type: organic
- Analytical purity: not specified
- Lot/batch No.: 06827
- Identification: S-145541
- CHF sample No: 37-61
- Date of receipt: 2-8-74

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
The nonfasted animals were maintained on appropriate Rockland diets and water ad libitum except during period of manipulation or confinement.

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: air
Details on inhalation exposure:
Concentrated vapor was generated in a gas washing bottle by passing dried air at 2.5 l/min through a fritted glass disc immersed to a depth of at least 1-1/2 inches in the chemical which is delivered to rats in a 9-liter glass exposure chamber. Mean vapor concentration is calculated from the loss in weight of the liquid or estimated from the vapor pressure at the actual temperature of the chemical during aerosol.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
0.083 mg/l
No. of animals per sex per dose:
6 animals/dose, sex unspecified
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Statistics:
LC50 was calculated by the moving average method based on a 14-day observation period.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 0.083 mg/L air
Exp. duration:
8 h
Mortality:
There were no mortalities.
Clinical signs:
No clinical signs were observed.
Body weight:
Weight change: 50-80 g
Gross pathology:
No remarkable findings were observed.

Applicant's summary and conclusion