Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets



Category name:

Justifications and discussions

Category definition:
Quaternary ammonium compounds
Category rationale:
Quaternary ammonium cations, also known as quats, are positively charged polyatomic ions of the structure NR4+, R being an alkyl group. Unlike the ammonium ion (NH4+) and the primary, secondary, or tertiary ammonium cations, the quaternary ammonium cations are permanently charged, independent of the pH of their solution. Quaternary ammonium salts or quaternary ammonium compounds are salts of quaternary ammonium cations with an anion. The tertiary amine moiety is caustic and lacks stability. In order to alleviate these characteristics, the tertiary amine is reacted with either methyl chloride, dimethyl sulphate or benzyl chloride to produce a more stable and less caustic quaternary amine salt. They are poorly metabolized and mainly excreted in a non-metabolized form. The toxicity and physical chemical properties of these quaternary ammonium salts are very similar, as would be expected. Quaternary ammonium salts of the esters of acrylic and methacrylic acid and dimethylaminopropyl acrylamide as well as diallyldimethylammonium chloride represent a category for the manufacture of cationic polyelectrolytes and , therefore, for purposes of the REACH registration.