Registration Dossier
Registration Dossier
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EC number: 238-485-8 | CAS number: 14484-69-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
A dermal absorption percentage for workers of 0.3% is assumed. For the general population a dermal absorption percentage of 0.85% is assumed.
Key value for chemical safety assessment
Additional information
Solids substances will only penetrate the skin in (aqueous) solution. Potassium tetrafluoroaluminate is a salt with a water solubility of 2.5 g/L. Once solved, the salt is hydrolysed to its ions F-, Al3+ and K+. The ions are hydrophylic and due to lack of lipophilicity, they will not have any affinity to skin(lipids). Therefore, skin absorption can only occur through the water that penetrates the skin and the maximum skin absorption is defined by the maximum water solubility of the salts and the maximum amount of water that can penetrate the skin.
The maximum amount of water that can penetrate the skin is determined to be 17 µL per 1 cm2 per 24 hours (Ten Berge, W. A simple dermal absorption model: derivation and application.Chemosphere 2009; 75(11):1440-5), which equals 6 µL per cm2 per 8 hours.
Skin penetration, dermal absorption percentage for workers
Since 6 µL of water can maximally penetrate 1 cm2 of skin per 8 hours, 6 x 2.5 = 15 µg of hydrolysed salt may penetrate 1 cm2 of skin per 8 hours. In an in vitro skin absorption experiment (according to OECD guideline 428), the application should mimic human exposure, normally 1-5 mg/cm2 (1000 -5000 µg/cm2). Thus, in case the skin penetration of potassium tetrafluoroaluminate would be experimentally determined according to OECD guideline 428 using 5 mg/cm2 as exposure condition, a skin penetration of 0.3% (15/5000) would be observed maximally. Therefore a skin penetration of potassium tetrafluoroaluminate of 0.3% is considered a worse-case situation for workers.
Skin penetration, dermal absorption percentage for general population
Since 17 µL of water can maximally penetrate 1 cm2 of skin per 24 hours, 17 x 2.5 = 42.5 µg of hydrolysed salt may penetrate 1 cm2 of skin per 24 hours. In an in vitro skin absorption experiment (according to OECD guideline 428), the application should mimic human exposure, normally 1-5 mg/cm2 (1000-5000 µg/cm2). Thus, in case the skin penetration of potassium tetrafluoroaluminate would be experimentally determined according to OECD guideline 428 using 5 mg/cm2 as exposure condition, a skin penetration of 0.85% (42.5/5000) would be observed maximally. Therefore a skin penetration of potassium tetrafluoroaluminate of 0.85% is considered a worse-case situation for the general population.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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