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EC number: 238-485-8 | CAS number: 14484-69-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
Description of key information
The LD50 value of LD50 ≤1.67 g cryolite/m2 from a field application study with blueberry flea beetle larvae is considered as the critical acute effect value for the assessment of oral exposure in terrestrial organisms. As the observed effect from cryolite as stomach poison is considered to be predominantly from the release of fluoride ions (U. S. EPA, 1996). The critical effect value of ≤1.13 g/m2 for potassium tetrafluoroaluminate is used in the assessment.
Key value for chemical safety assessment
Additional information
For potassium tetrafluoroaluminate exposure via soil (uptake from soil matrix), no data are available. However, it should be noted, that due to the dissolution behaviour, it can be expected, that when potassium tetrafluoroaluminate is mixed to soil matrix and gets in contact with pore water, it is dissolved to different aluminum and fluoride species and no exposure to dissolved potassium tetrafluoroaluminate occurs in soil.
Like cryolite, potassium tetrafluoroaluminate can also be deposited in dust and in suspended form for some uses, where a considerable amount of potassium tetrafluoroaluminate can be expected to remain in particulate form. Ingestion of potassium tetrafluoroaluminate is expected to be the relevant route of exposure. Cryolite is considered to act predominantly as stomach poison while it releases fluoride ions (U.S. EPA, 1996). Fluoride ions in turn form complexes with metal containing enzymes in stomach (Corbett et al., 1974). For cryolite, two studies are available on the target organisms beet armyworm (Spondoptera exigua; Yee and Toscano, 1998) and tobacco caterpillar (Spodoptera litura; Prasad et al., 2000) these studies provide evidence that ingestion as route of exposure and particulate form as form of exposure in combination cause increased response to increased dose.
For cryolite two other studies are available with honeybee (Apis mellifera; Atkins and Kellum, 1986) and blueberry flea beetle larvae (Altica sylvia; Forsythe and Collins, 1994) these studies could be used in a tentative manner for PNEC derivation related to exposure similar to insecticidal application. The honeybee brood LD50 of 224.5 g cryolite/m2 is related to the application rate as well as the results with the blueberry flea beetle larvae (LD50 ≤1.67 g cryolite/m2). Target species blueberry flea beetle (short term field test) seemed to be more sensitive than honeybee brood. Despite of the uncertainty regarding to whether a proper dose-response resulted in the test with blueberry flea beetle larvae, the lower application rate of 1.67 g/m2 from this study is considered as the critical acute effect value.
The contents of fluoride, expressed as a percentage of the molar weight in both substances are practically identical, namely 54% for cryolite and 53.5% for potassium tetrafluoroaluminate. Taking into account normal physiological roles of sodium and potassium cations, their presence in the structures of the substances is not expected to lead to any significant differences in the ecotoxicity of the two substances (for details see Reporting Format as attached to the respective IUCLID entry and CSR Appendix B.4). As a result no safety factor is applied. Instead, the effect concentrations will be corrected for molecular weight. Thus, the corrected critical effect value of 1.13 g/m2 is used in the assessment.
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