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Description of key information

Based on the available study, the read-across candidate multiconstituent aluminium potassium fluoride does not induce sensory irritation in the respiratory tract. Therefore, it is also not expected that potassium tetrafluoroaluminate will induce a sensory irritation response.

Additional information

Data on sensory irritation are available on a structural analogue multiconstituent aluminium potassium fluoride. Multiconstituent aluminium potassium fluoride is a multi-constituent substance containing ca. 70% of KAlF4and ca. 30% of higher homological penta- and hexafluoroaluminic acids, K2AlF5and K3AlF6.The presence of these higher homological salts is, however, not expected to alter significantly the physico-chemical and toxicological properties of multiconstituent aluminium potassium fluoride in comparison to potassium tetrafluoroaluminate.

The airway irritating properties of multiconstituent aluminium potassium fluoride were studied by exposing three groups of four male mice to test atmospheres containing the substance at concentrations of 283, 592 and 604 mg/m3 for a single period of 20, 20 and 30 minutes, respectively (TNO, 1999b).

A decrease in breathing rate or post-inspiratory apnoea were not seen in the breathing pattern. During exposure, no changes in behaviour were seen. No abnormalities or clinical signs were seen during the 7-day observation period. None of the mice died. Dose (exposure*time) related weight decrease was not observed. Abnormalities at necropsy consisted primarily of discoloured areas on the lungs to a varying extent in the highest concentration group.

From the results of the present study in mice, it was concluded that a sensory irritation response of inhalable particles of multiconstituent aluminium potassium fluoride at the technically highest attainable concentration under the conditions of this study (604 mg/m3) was not found. Therefore, it is also not expected that potassium tetrafluoroaluminate will induce a sensory irritation response.