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EC number: 212-755-5 | CAS number: 866-84-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
No reliable information is available for tripotassium citrate (CAS number 866 -84 -2). Information is available for the closely related substances, sodium dihydrogen citrate and citric acid. Information is available for citric acid (CAS number 77-92-9 ) and sodium dihydrogen citrate (CAS number 18996-35-5) from reliable studies for mutagenicity to bacteria. There is also information available from studies of lower reliability that tripotassium citrate does not cause mutagenicity to bacteris, and that citric acid does not cause chromosome aberrations in vitro. Information from reliable studies indicate that citric acid does not cause chromosome damage in somatic or in germ cells in vivo. A recent publication described positive results in mammalian cells, including a chromosome aberration analysis and an in vitro micronucleus assay. The micronucleus assay was chosen as key, as the method was close to the draft guideline and effects were observed. It is considered that this positive result does not affect the overall genetic toxicity assessment of this substance as the effects seen in vitro were not observed in vivo and are not considered biologically relevant
Short description of key information:
In vitro:Gene mutation (Bacterial reverse mutation assay / Ames test): read across from sodium dihydrogen citrate: negative with and without activation in all strains tested (similar to OECD TG 471)
Cytogenicity in mammalian cells: read across from citric acid: positive for induction of micronuclei in cultured human lymphocytes without activation (similar to OECD draft TG 487)
In vivo
Mammalian Chromosome Aberration test in rat (oral gavage administration) (similar to OECD TG 475): read across from citric acid: negative
Rat dominant lethal Assay (oral gavage administration) (similar to EU 22): read across from citric acid: negative
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The available data, obtained by read-across from citric acid and sodium dihydrogen citrate, is sufficient to fulfil the information requirements for this endpoint. Information available in the public domain on tests carried out on other salts of this metal indicates that the potassium ions are not expected to contribute to the genetic toxicity of the substance. Additionally, the substance will dissociate when in solution, so the test organisms will be exposed to the citrate and the metal ions separately.
Therefore, it is possible to read across from one citrate salt to another and conduct the hazard assessment for this substance, tripotassium citrate, on the properties of citric acid and sodium dihydrogen citrate. In vivo studies on citric acid showed no effects, so it is concluded that classification for mutagenicity is not required.
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