Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

basic toxicokinetics
Type of information:
other: report
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The data was obtained from a collection of reliable data which has been subject to peer-review and in which the original data sources are traceable.

Data source

Reference Type:
secondary source

Materials and methods

Principles of method if other than guideline:
The data available on citric acid and the citrate salts has been assembled into one report.

Test material

Constituent 1
Chemical structure
Reference substance name:
Tripotassium citrate
EC Number:
EC Name:
Tripotassium citrate
Cas Number:
Molecular formula:
tripotassium citrate

Results and discussion

Any other information on results incl. tables

Please refer to attached report.

Applicant's summary and conclusion

Citric acid is a metabolic intermediate vital to the TCA respiration pathway found in all animal and plant cells. There is little evience that citric acid and the citrate salts have deleterious effects, even in large doses. Indeed there is some support for the fact that citric acid in the human diet is favourable by inhibiting the formation of calcium oxalate kidney and bladder stones. This statement is applicable to the citrate salts since once absorbed citrate salts will dissociate into citric acid and their counter-ion.