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EC number: 921-024-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2 035 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 6
- Modified dose descriptor starting point:
- NOAEC
- Explanation for the modification of the dose descriptor starting point:
In order to account for differences between experimental and human exposure conditions, the starting point was modified: Corrected NAEC = 24300 mg/m3 x (6/8) x (6.7/10) = 12211 mg/m3. DNEL long-term inhalation = 12211 mg/m3 / (2 (subchronic to chronic) x 3 (intraspecies)) = 2035 mg/m3.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 773 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 6
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
The pattern of identified uses described for hydrocarbons, C6-C7, n-alkanes, isoalkanes, cyclics, <5% n-hexane includes short-term peak exposure by inhalation and the dermal route as well as long-term repeated exposure by inhalation and the dermal route. In the case of short-term exposure, it is not possible to derive a DNEL for systemic effects, since CNS toxicity (narcotic effects) and local irritation on the skin are the leading effects. Therefore, appropriate risk management measures will be identified.
Assessment factors were chosen on the basis of ECETOC (2003) and other, more recent, information. For route to route extrapolation, absorption differences were not taken into account.
CNS Effects
In studies in rodents, 8 hours of exposure to n-octane (Lammers et al., 2010) did not produce any acute CNS effects at levels up to 14,000 mg/m3. Similarly, there were no acute CNS effects associated with exposure to iso-octane for 8 hours at 14,000 mg/m3 (Lammers et al., 2001a). In a study of a mixed C7 cycloparaffinic solvent, there was evidence of acute CNS effects at 14,000 mg/m3, but no effects at 4200 mg/m3 (Lammers et al., 2001a). In older studies, the anaesthetic levels for n-heptane and iso-octane in mice were reported as greater than 8000 ppm (approximately 32,000 mg/m3 ) (Swan et al., 1974).
In humans heptane was reported to produce a slight vertigo in 6 minutes at a concentration of 1000 ppm (approximately 4000 mg/m3) (Patty and Yant, 1929).
In summary the animal and human data indicate that the worker long term inhalation DNEL (approximately 2000 mg/m3) is also protective for short term effects including acute CNS effects and respiratory irritation.
References:
Lammers , J. et al. (2010). Neurobehavioral effects of acute exposures to(n-) paraffins. International Journal of Toxicology (submitted for publication).
Lammers, J. et al. (2001a). The effects of short term inhalatory exposure to iso-octane on behavior in the rat. TNO Report V99.430. (unpublished laboratory report).
Lammers, J. et al. (2001b). The effects of short-term inhalatory exposure to Cypar 7 on behavior in the rats. TNO Report V99.1115. (unpublished laboratory report).
Swan, H. et al. (1974). Acute inhalation toxicology of volatile hydrocarbons. American Industrial Hygiene Association Journal 35:511-518.
Patty, F., and Yant, W. (1929). Odor intensity and symptoms produced by commercial propane, butane, pentane, hexane and heptane. Bureau of Mines. R.I. 2979.
ECETOC (2003). Derivation of assessment factors for human health risk assessment. Technical report No. 86, (European Centre for Ecotoxicology and Toxicology of Chemicals).
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 608 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 699 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 699 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
The pattern of identified uses described for hydrocarbons, C6-C7, n-alkanes, isoalkanes, cyclics, <5% n-hexane includes short-term peak exposure by inhalation and the dermal route as well as long-term repeated exposure by inhalation and the dermal route. In the case of short-term exposure, it is not possible to derive a DNEL for systemic effects, since CNS toxicity (narcotic effects) and local irritation on the skin are the leading effects.Therefore, appropriate risk management measures will be identified.
Assessment factors were chosen on the basis of ECETOC (2003) and other, more recent, information. For route to route extrapolation, absorption differences were not taken into account.
CNS Effects
In studies in rodents, 8 hours of exposure to n-octane (Lammers et al., 2010) did not produce any acute CNS effects at levels up to 14,000 mg/m3. Similarly, there were no acute CNS effects associated with exposure to iso-octane for 8 hours at 14,000 mg/m3 (Lammers et al., 2001a).
In a study of a mixed C7 cycloparaffinic solvent, there was evidence of acute CNS effects at 14,000 mg/m3, but no effects at 4200 mg/m3 (Lammers et al., 2001a).
In older studies, the anaesthetic levels for n-heptane and iso-octane in mice were reported as greater than 8000 ppm (approximately 32,000 mg/m3 ) (Swan et al., 1974).
In humans heptane was reported to produce a slight vertigo in 6 minutes at a concentration of 1000 ppm (approximately 4000 mg/m3) (Patty and Yant, 1929).
In summary the animal and human data indicate that the worker long term inhalation DNEL (approximately 2000 mg/m3) is also protective for short term effects including acute CNS effects and respiratory irritation.
References:
Lammers , J. et al.(2010). Neurobehavioral effects of acute exposures to(n-) paraffins. International Journal of Toxicology (submitted for publication).
Lammers, J. et al. (2001a). The effects of short term inhalatory exposure to iso-octane on behavior in the rat. TNO Report V99.430. (unpublished laboratory report).
Lammers, J. et al. (2001b). The effects of short-term inhalatory exposure to Cypar 7 on behavior in the rats. TNO Report V99.1115. (unpublished laboratory report).
Swan, H. et al. (1974). Acute inhalation toxicology of volatile hydrocarbons. American Industrial Hygiene Association Journal 35:511-518.
Patty, F., and Yant, W. (1929). Odor intensity and symptoms produced by commercial propane, butane, pentane, hexane and heptane.
Bureau of Mines. R.I. 2979. ECETOC (2003). Derivation of assessment factors for human health risk assessment. Technical report No. 86, (European Centre for Ecotoxicology and Toxicology of Chemicals).
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