Registration Dossier

Toxicological information

Endpoint summary

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Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Additional information:

There are no skin sensitisation studies available for triacetoxyethylsilane itself. However, two relevant in vivo skin sensitisation studies are available as supporting information. In the first test (BSL, 2004), a preparation containing a mixture of approximately 4.5% (total) triacetoxyethylsilane and the related substance triacetoxymethylsilane was found to be not sensitisting in a test conducted according to the Buehler method. In a second test (Hazelton, 1990), a preparation containing approximately 5% triacetoxymethylsilane was not sensitising, also using the Buehler method. These preparations are similar to products marketed for professional and consumer sealant applications and the studies therefore indicate that there is no sensitisation potential from use of the preparations.


Migrated from Short description of key information:
There are no skin sensitisation studies available.

However, in accordance with Column 2 of REACH Annex VII, the in vivo skin sensitisation study (required in Section 8.3) does not need to be conducted as the available information indicates that the substance meets the criteria for classification as corrosive to skin.

Justification for classification or non-classification

Triacetoxyethylsilane is not classified for skin sensitisation under Regulation 1272/2008/EC.