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EC number: 424-110-7 | CAS number: 194602-23-8 UK-143,108
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Boiling point
Administrative data
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 August and 28 September 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted according to OECD and EUand in accordance with GLP. Study material is well characterized.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Version / remarks:
- Commission Directive 92/69/EEC, A2 (differential scanning calorimetry method).
- Deviations:
- no
- Principles of method if other than guideline:
- The technique of Differential Scanning Calorimetry was employed, using the methods described in the ASTME standards: 537-76 (the standard method for assessing the thermal stability of chemicals by methods of differential thermal analysis), 473-85 (Standard definition of terms relating to thermal analysis) and 472-86 (Standard practice for reporting thermoanalytical data) and in accordance with OECD Guideline 113.
Test substance was weighed into five aluminium crucibles (ca 9 mg in each) and aluminium oxide (ca
9 mg) weighed into another crucible. A perforated lid was cold welded onto each crucible.
Preliminary tests were performed to determine the melting/decomposition temperature range and the boiling/decomposition temperature range. The definitive test was performed in duplicate, using a fresh sample in each case.
The crucible containing the aluminium oxide was used as a reference for all the tests. A nitrogen purge of 30 ml/minute was employed in each test.
The calorimeter was connected to a printer and traces of each test obtained. The test substances crucibles were inspected after each test. - GLP compliance:
- yes
- Type of method:
- differential scanning calorimetry
Test material
- Test material form:
- other: White to off white crystalline solid
- Details on test material:
- Identity: UK-143,108
Chemical name: 2-Ethoxy-5-(4-methyl-1- piperazinesulphonyl)benzoic acid
Expiry: 19 November 1995
Purity: 99.6% (excluding organic solvents)
Appearance: White to off white crystalline solid
Storage conditions: Dark at room temperature
Date received: 19 May 1995
Constituent 1
Results and discussion
Boiling point
- Key result
- Boiling pt.:
- > 275 - < 310 °C
- Atm. press.:
- other: atmosphere
- Decomposition:
- yes
- Remarks:
- at melting
- Decomp. temp.:
- > 189 - < 196 °C
Any other information on results incl. tables
Two endotherms were recorded from test substance scans The first endotherm between 189°C and 207°C (test 2 and 3) agreed with the melting point determination (test Al). A second DSC on the same sample showed no endotherm indicating decomposition on melting. The second endotherm between 275°C and 310°C indicated decomposition at the boiling temperature as inspection of the test crucible after the test showed that a red/brown solid had been produced
Applicant's summary and conclusion
- Conclusions:
- UK-143,108 underwent decomposition on melting between 189°C and 196°C and on boiling between 275°C and 310°C.
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