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Physical & Chemical properties

Water solubility

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Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 August and 28 September 1995.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: done under GLP and OECD method

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report Date:
1997

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Principles of method if other than guideline:
Test substance (ca 1.0 g) was combined with distilled water (20 ml) in each of six 100 ml conical flasks. The flasks were firmly stoppered, covered in aluminium foil to exclude daylight and stirred at 30°C prior to equilibration at the test temperature of 20°C. The flask contents were stirred as indicated below:

Test Pre-equilibration Equilibration
(30°C) (20°C)
IA, 1B 3 Days 1 Day
2A, 2B 2 Days 1 Day
3A, 3B 1 Day 1 Day

Blanks were prepared and stirred as for the test solutions, omitting the test substance
GLP compliance:
yes
Type of method:
flask method
Remarks:
flask-stirring method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: White to off white crystalline solid
Details on test material:
Identity: UK-143,108
Chemical name: 2-Ethoxy-5-(4-methyl-1- piperazinesulphonyl)benzoic acid
Expiry: 19 November 1995
Purity: 99.6% (excluding organic solvents)
Appearance: White to off white crystalline solid
Storage conditions: Dark at room temperature
Date received: 19 May 1995

Results and discussion

Water solubility
Water solubility:
10.2 g/L
Temp.:
20 °C
pH:
> 5.54 - < 5.8
Remarks on result:
other: +- 1C
Details on results:
recoveries of 100.0 and 99.8% (mean 99.9%).
No peaks were observed at the retention time of the test substance for either of the blanks showing that the analytical procedure was free from interferences

Any other information on results incl. tables

 

 

Testsample

 

 

Integratedpeakarea

 

 

Water solubility(g/l)

 

Meanwatersolubilityforeach test

(g/l)

 

Overall meanwatersolubility(g/l)

 

 

pH

 

 

IA

22125246

 

10.117

 

10.359

 

 

 

 

 

10.229

 

5.54

1B

23193454

10.602

 

5.63

 

2A

2B

 

22278564

22436666

 

10.186

10.258

 

10.222

 

5.71

5.80

 

3A

 

21622814

 

9.8885

 

10.107

 

5.73

3B

22583764

10.325

5.73

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of UK-143,108 has been determined as: 10.2 g/l at 20°C.

The pH at the saturation concentration ranged from 5.54 to 5.80