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Melting point / freezing point

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melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 August and 28 September 1995.
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted followin OECD/EU guideline and in accordance with GLP. Study material is well characterized.

Data source

Reference Type:
study report
Report date:

Materials and methods

Test guideline
according to guideline
EU Method A.1 (Melting / Freezing Temperature)
Principles of method if other than guideline:
Dried test substance (ca I g) was pulverised to a fine powder, using a pestle and mortar. A small amount of the test substance was tightly packed into a capillary tube to a height of 1 mm. The melting point apparatus was increased until approximately l0°C below the expected melting temperature. The capillary tube was then placed in the apparatus and the heating rate adjusted to 1°C/minute until the sample had completely melted.

The procedure was repeated using a fresh sample
GLP compliance:
Type of method:
other: metal block method

Test material

Constituent 1
Test material form:
other: White to off white crystalline solid
Details on test material:
Identity: UK-143,108

Chemical name: 2-Ethoxy-5-(4-methyl-1- piperazinesulphonyl)benzoic acid

Expiry: 19 November 1995

Purity: 99.6% (excluding organic solvents)

Appearance: White to off white crystalline solid

Storage conditions: Dark at room temperature

Date received: 19 May 1995

Results and discussion

Melting / freezing point
Melting / freezing pt.:
>= 192 - <= 193 °C
Atm. press.:
ca. 101.3 kPa
Remarks on result:
other: Measured at atmospheric pressure

Any other information on results incl. tables

The test substance began to darken at 189°C, before melting to a dark brown liquid.

Applicant's summary and conclusion

The melting temperature of UK-143,108 was 192.0 to 193.0°C.