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Registration Dossier
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EC number: 424-110-7 | CAS number: 194602-23-8 UK-143,108
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 August and 28 September 1995.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted followin OECD/EU guideline and in accordance with GLP. Study material is well characterized.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Principles of method if other than guideline:
- Dried test substance (ca I g) was pulverised to a fine powder, using a pestle and mortar. A small amount of the test substance was tightly packed into a capillary tube to a height of 1 mm. The melting point apparatus was increased until approximately l0°C below the expected melting temperature. The capillary tube was then placed in the apparatus and the heating rate adjusted to 1°C/minute until the sample had completely melted.
The procedure was repeated using a fresh sample - GLP compliance:
- yes
- Type of method:
- other: metal block method
Test material
- Test material form:
- other: White to off white crystalline solid
- Details on test material:
- Identity: UK-143,108
Chemical name: 2-Ethoxy-5-(4-methyl-1- piperazinesulphonyl)benzoic acid
Expiry: 19 November 1995
Purity: 99.6% (excluding organic solvents)
Appearance: White to off white crystalline solid
Storage conditions: Dark at room temperature
Date received: 19 May 1995
Constituent 1
Results and discussion
Melting / freezing point
- Melting / freezing pt.:
- >= 192 - <= 193 °C
- Atm. press.:
- ca. 101.3 kPa
- Remarks on result:
- other: Measured at atmospheric pressure
Any other information on results incl. tables
The test substance began to darken at 189°C, before melting to a dark brown liquid.
Applicant's summary and conclusion
- Conclusions:
- The melting temperature of UK-143,108 was 192.0 to 193.0°C.
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