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Physical & Chemical properties

Explosiveness

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Administrative data

Endpoint:
explosive properties of explosives
Type of information:
experimental study
Adequacy of study:
key study
Study period:
21 October 1996 and 9 January 1997
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: done under GLP and OECD method

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report date:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.14 (Explosive properties)
Principles of method if other than guideline:
PERFORMANCE OF THE TEST

Test substance (ca 5 g) was sieved through a 0.5 mm sieve and dried under a vacuum and over phosphorus pentoxide. The dried material was used in both the shock and friction tests.




THERMAL SENSITIVITY (EFFECT OF A FLAME)

The heating rate of the propane burners was checked using a steel tube containing 27 cm3 dibutyl phthalate, restricted with a 1.5 mm diameter orifice and found to be 211.8° C/min between the temperatures of 135°C and 285°C (within the specified rate of 185 to 2 I 5°C/min). A steel tube was filled with test compound (ca 23 g), a 6 mm diameter orifice plate was fitted, and the tube placed in the Koenen apparatus. The burners were ignited and left on for 5 minutes (unless an explosion was recorded before this time).

Three tests were carried out using a 6 mm diameter orifice place, using a fresh sample and a new tube each time. A further three tests were then performed using a 2 mm diameter orifice place.




MECHANICAL SENSITIVITY (SHOCK)


Dried test substance (40 mm3

was put in the die assembly (the die assembly had been degreased with

acetone) and placed on the anvil in the drop hammer apparatus. A 10 kg weight was released from a height of 0.4 m. The test was performed six times using a fresh sample on each occasion.



j MECHANICAL SENSITMTY (FRICTION)


Dried test substance (I0 mm 3

was placed on the porcelain plate, and the porcelain peg drawn to and

from across with a loading of 360 N. The test was performed six times, using a fresh sample on each occasion.
GLP compliance:
yes

Test material

Constituent 1
Test material form:
solid: crystalline
Details on test material:
Date Recieved: 2 October 1996
Intended use: Pharmaceutical intermediate

Results and discussion

Small-scale preliminary testsopen allclose all
Parameter:
other: More sensitive to shock than m-dinitrobenzene
Remarks:
migrated information
Remarks on result:
other: no data
Parameter:
other: More sensitive to friction than m-dinitrobenzene
Remarks:
migrated information
Remarks on result:
other: no data
Parameter:
other: Explosive under influence of flame
Remarks:
migrated information
Remarks on result:
negative (not further specified)
Remarks:
There was no explosions or deformations although the test substance did ignite
Parameter:
other: Explosive (not specified)
Remarks:
migrated information
Remarks on result:
negative (not further specified)

Applicant's summary and conclusion

Interpretation of results:
non explosive
Conclusions:
Under the conditions of this test, UK-143,108 does not exhibit explosive properties