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EC number: 424-110-7 | CAS number: 194602-23-8 UK-143,108
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://www.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 August and 5 September 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to OECD and in accordance with GLP. The study material is well characterize
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Test material form:
- solid: crystalline
- Details on test material:
- Intended use: Pharmaceutical intermediate
Expiry date: No data available
Purity: 99.6% excluding organic solvents
Appearance: White to off-white crystalline solid
Storage conditions: Room temperature
Date received: 19 May 1995
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Olac Ltd, Bicester, Oxon, England
- Age at study initiation: 4-7 weeks
- Weight at study initiation: 112 to 146 g
- Fasting period before study: Were fasted but no data on durations
- Housing: housed in groups of up to five rats of the same sex in metal cages with wire mesh floors in Building Rl4 Room 6
- Diet (e.g. ad libitum): A standard laboratory rodent diet (SOS LAD 1) and drinking water were provided ad libitum. Access to food only was prevented overnight prior to and approximately 4 hours after dosing.
- Acclimation period: 12 days before
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): not controlled but was anticipated to be in the range 30 - 70 %
- Air changes (per hr): maintained at 10 to 15 air changes per hour
- Photoperiod (hrs dark / hrs light):time switch to provide 12 hours of artificial light (0700 - 1900 hours) in each 24-hour period.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Single dose by oral gavage
- Doses:
- A preliminary study was carried out by dosing one female rat at 500 or 2000 mg/kg bodyweight.
Rats were given a single dose by oral gavage of the test substance, formulated in distilled water, at a dose level of 2000 mg/kg bodyweight in main test - No. of animals per sex per dose:
- 10 males/females
- Control animals:
- no
- Details on study design:
- Preliminary study
A preliminary study was carried out by dosing one female rat at 500 or 2000 mg/kg bodyweight. Main study
A group of ten rats (five males and five females) was treated at 2000 mg/kg bodyweight. The dose level was selected on the basis of the preliminary study.
Control animals
No control animals were included in this study.
ADMINISTRATION OF TEST SUBSTANCE
The appropriate dose volume of the test substance was administered to each rat by oral gavage using a syringe and plastic catheter (8 choke).
The day of dosing was designated Day 1.
Results and discussion
- Preliminary study:
- The results of the preliminary study indicated that the acute lethal oral dose to female rats of UK- 143, I 08 was greater than 2000 mg/kg bodyweight
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- discriminating dose
- Effect level:
- ca. 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No Deaths
- Sex:
- female
- Dose descriptor:
- discriminating dose
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No Deaths
- Mortality:
- The results of the preliminary study indicated that the acute lethal oral dose to female rats of UK- 143, I 08 was greater than 2000 mg/kg bodyweight.
- Clinical signs:
- other: Piloerection was observed in all rats within five minutes of dosing and was accompanied at this time in one male and one female rat only by increased salivation. There were no other clinical signs and recovery, as judged by external appearance and beha
- Gross pathology:
- Macroscopic examination of animals killed on Day 15 revealed no abnormalities
Applicant's summary and conclusion
- Interpretation of results:
- other: discriminating oral dose 2000 mg/kg bodyweight
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The discriminating oral dose to rats of UK-143, 108 was established to be 2000 mg/kg bodyweight
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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