Registration Dossier
Registration Dossier
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EC number: 601-431-2 | CAS number: 1164-92-7
Endpoint summary
Administrative data
Description of key information
Dermal local tolerance (Rat, GLP, not audited report; OECD 402): not irritant
[Schering AG, Report X296; 1998-09-24]
Occular local tolerance (Rabbit, GLP, not audited report; OECD 405): not irritant acc. EU criteria
[Schering AG, Report X362; 1999-07-21]
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
After single dermal administration of ZK 5180 to 3 male and 3 female rats at a dose of 570 -594 mg/male rat and 436 -448 mg/female rat of the original compound, no compound related local findings were observed after removing of the bandages at the time points 1, 24, 48 and 72 hours. [Schering AG, Report X296; 1998-09-24]
After single administration of ZK 5180 into the conjuctival sac of the rabbit eye (2 male; 2 female rabbits) slight to moderate reddening and slight to severe swelling of the conjuctivae were observed in all animals on the application day, which was fully reversible by day 3 after administration. [Schering AG, Report X362; 1999-07-21]
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
There is no classification required according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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