Registration Dossier
Registration Dossier
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EC number: 601-431-2 | CAS number: 1164-92-7
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- Jan 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well documented GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 17 beta-Acetoxy-5 alpha-androstan-3-one
- EC Number:
- 601-431-2
- Cas Number:
- 1164-92-7
- Molecular formula:
- C21 H32 O3
- IUPAC Name:
- 17 beta-Acetoxy-5 alpha-androstan-3-one
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.8 - < 1.5 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- other: TOC
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.8 - < 1.5 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- other: TOC
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.8 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- other: TOC
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 1.5 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- other: TOC
- Basis for effect:
- mortality
Applicant's summary and conclusion
- Conclusions:
- The EC50/48 hours of androstanolone acetate (ZK 5180) for Daphnia magna was between 0.8 and 1.5 mg/L.
- Executive summary:
20 Daphnia were exposed to different concentrations between 0.2 and 1.5 mg/L of ZK5180 and a control group.
The concentration of the highest test concentration was analysed at 0 and 48h by a TOC analyser and the concentration was calculated and extrapolated to the other dilutions.
Daphnids were immobilized at the highest concentration 13 at 14 hours and 15 at 48 hours. Thuis, the EC50 was determined between 0.8 and 1.5 mg/L.
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