Registration Dossier
Registration Dossier
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EC number: 601-431-2 | CAS number: 1164-92-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- July 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well documented GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 17 beta-Acetoxy-5 alpha-androstan-3-one
- EC Number:
- 601-431-2
- Cas Number:
- 1164-92-7
- Molecular formula:
- C21 H32 O3
- IUPAC Name:
- 17 beta-Acetoxy-5 alpha-androstan-3-one
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.06 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- other: TOC
- Basis for effect:
- growth rate
- Remarks on result:
- other: 0.01-0.14 mg/L 95% conf. int.
Applicant's summary and conclusion
- Conclusions:
- The EC50/72 hours of androstanolone acetate (ZK 5180) in the green algae Desmodesmus subspicatus was 0.06 mg/L.
- Executive summary:
The green algae Scendesmus subspicatus (=Desmodesmus subspicatus) were incubated with ZK5180 at different concentrations between 0.02 and 1.39 mg/L over aperiod of 72 hours. Cell density was measured daily using a fluorescence photometer.
All teratment groups showed a concentration-related inhibiotion of growth. The EC50/72 hours for the specific growth rate was determined with 0.06 mg/L (95% conf interval 0.01 -0.14 mg/L).
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