Registration Dossier
Registration Dossier
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EC number: 601-431-2 | CAS number: 1164-92-7
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- Feb 1999-March 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well documented GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 17 beta-Acetoxy-5 alpha-androstan-3-one
- EC Number:
- 601-431-2
- Cas Number:
- 1164-92-7
- Molecular formula:
- C21 H32 O3
- IUPAC Name:
- 17 beta-Acetoxy-5 alpha-androstan-3-one
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 10 mg/L
- Based on:
- DOC
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 85
- Sampling time:
- 28 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 68
- Sampling time:
- 18 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 19
- Sampling time:
- 7 d
- Details on results:
- The reference compound (sodium acetate was degraded to 71% at day 9 and 100 % at day 28.
The toxicity control showed degradation rates of 70 at day 14 and 93% at the end of incubation
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable, but failing 10-day window
- Conclusions:
- Androstenolone acetate is rapidly biodegradable, but failed to meet the stringent criteria for ready biodegradability.
- Executive summary:
The test substance was incubated with activated sludge originating from a municipal sewage treatment plant pimarily dealing with domestic sewage. The incubation period was 28 days. The test compound was introduced at a concentration of 10 mg/l as carbon Additionally, a reference substance (sodium acetate) was incubated and a toxicity control. CO2 produced was trapped by bariumhydroxide and sampled at day 3, 4, 7, 9, 14, 18, 23, 28 and 30 (after acification).
The test substance was degraded to 85%, but failed to meet the 10 day window. 60% degradation was reached 11 days after degradation passed 10%.
The reference compound was degraded to more than 60% at day 9, fufilling the validity criterion. The toxcity control showed no inhibitory effect of the test compound.
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