Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 218-487-5 | CAS number: 2162-74-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- further information relevant for the PBT assessment is necessary
- Justification:
Overall Conclusion
Criteria for assessing PBT properties are defined in Annex XIII of REACH Regulation (EC) No. 1907/2006. Further details are laid down in ECHA Guidance on Information Requirements and Chemical Safety Assessment; Chapter R.11: PBT/vPvB Assessment (November 2014). The PBT or vPvB assessment should be based on assessments for each parameter (i.e. P or vP, B or vB and T). Substances are only assigned as PBT or vPvB when they fulfil the criteria for all three properties persistency, bioaccumulation and toxicity (i.e. PBT substance) or both criteria (very persistent and very bioaccumulative) in case of vPvB.
The assessment of the persistence of the registered substance is performed using the revised integrated assessment and testing strategy (ITS) as in ECHA REACH Guidance Chapter R.11 (June, 2017). So far, the assessment of persistency can be based on available half-life data of the study on ready biodegradability in water and calculated degradation half-lives from the results of the study on hydrolysis as described in ECHA REACH Guidance Chapter R.7b (February, 2016).
To enable the possibility to draw a definitive conclusion on persistence as in ECHA REACH Guidance Chapter R.11 (November, 2017), higher tier information in addition to the screening information are needed to conclude the P/vP-assessment on all three compartments. Hence, simulation tests are necessary and are being currently prepared to assess biodegradation in sediment and soil. The respective studies are scheduled in a tiered approach and results will be included in an additional update of the technical dossier, containing a definitive conclusion on persistence as well as a final PBT assessment for the registered substance. This can also cover additional data on the e-fate of hydrolysis products.
Aside from the registered substance, the final hydrolysis product 2,6-diisopropylaniline (DIPA) has been assessed towards its potential PBT and vPvB properties as well. Based on the assessment described in the subsections above, DIPA is not a PBT / vPvB substance.
Thus, overall further information relevant for the pbt assessment is necessary to conclude if the registered substance has to be regarded as not PBT and not vP/vB also.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
