Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-487-5 | CAS number: 2162-74-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1962
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: very old report only minimal information given
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
- Report date:
- 1962
- Reference Type:
- other:
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Carbodiimide was administered in an oily solution to male rats via intraperitoneal injection. The animals were observed for at least 5 days and clinical signs and mortality monitored.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Bis(2,6-diisopropylphenyl)carbodiimide
- EC Number:
- 218-487-5
- EC Name:
- Bis(2,6-diisopropylphenyl)carbodiimide
- Cas Number:
- 2162-74-5
- Molecular formula:
- C25H34N2
- IUPAC Name:
- N,N'-bis[2,6-bis(propan-2-yl)phenyl]methanediimine
- Details on test material:
- - Name of test material (as cited in study report): Carbodiimid 4175
- Physical state: solid (bright yellow to brown and practically odour-less crystalline substance)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino, unspecified strain
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no further details available
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: oil, unspecified
- Details on exposure:
- no data
- Doses:
- 0.01 g/kg (0.2% in oil)
0.025 g/kg (0.5% in oil)
0,05 g/kg (0.5% in oil)
0.10 g/kg (1% in oil)
0.25 g/kg (5% in oil)
0.5 g/kg (10% in oil) - No. of animals per sex per dose:
- 5 (male rats only)
- Control animals:
- not specified
- Details on study design:
- no further details
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- >= 0.01 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 0.2 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LC100
- Effect level:
- 0.5 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0.01 g/kg: no mortality
0.025 g/kg: no mortality
0.05 g/kg: no mortality
0.1 g/kg: no mortality
0.25 g/kg: 4 dead rats
0.50 g/kg: 5 dead rats - Clinical signs:
- 0.01 g/kg: no clinical signs
0.025 g/kg: 5 animals with symptoms
0.05 g/kg: 5 animals with symptoms
0.10 g/kg: 5 animals with symptoms
0.25 g/kg: 5 animals with symptoms
0.50 g/kg: 5 animals with symptoms
Symptoms were similar as the symptoms which occurred after oral exposure (reduced general condition, spastic posture, expanded abdomen (start 1 hour after application, reversible within 3 days)). - Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no further details available
Applicant's summary and conclusion
- Conclusions:
- The study was considered to be of low reliability (reliability Klimisch 3), because of the limited information available. The test material did induce mortality and treatment-related clinical signs in the dose group of 500 mg/kg bw (100 % mortality) and in dose group 250 mg/kg bw (80 % mortality). In the dose groups 10, 25, 50 and 100 mg/kg no mortality was evident.
- Executive summary:
The acute intraperitoneal toxicity of bis(2,6-diisopropylphenyl)-carbodiimide was investigated in rats (Kimmerle, 1962). The test item was administered in oil in concentrations of 10, 25, 50, 100, 250 and 500 mg/kg bw via intraperitoneal injection to male albino rats (groups of 5). Mortality occurred with all animals in the group dosed with 500 mg/kg bw. The symptoms were poor general condition, hunched posture and expanded abdomen. 4 animals died in the group dosed with 250 mg/kg bw. No mortality was found in the dose groups of 10, 25, 50 and 100 mg/kg bw. An LD50 of ca. 200 mg/kg bw was identified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
