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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP, near guideline study, published in peer reviewed literature, limitations in design and/or reporting but otherwise adequate for assessment.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1962

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Single dermal dose under occlusion followed by observation for 14 days.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
m-xylene
EC Number:
203-576-3
EC Name:
m-xylene
Cas Number:
108-38-3
Molecular formula:
C8H10
IUPAC Name:
m-xylene
Details on test material:
no further details

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
Weight at study initiation: 2.5-3.5 kg


Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Fur removed from the entire trunk by clipping and the dose retained beneath an impervious plastic film for 24 hours, after which the film was removed.
Duration of exposure:
24 hours
Doses:
Not reported
No. of animals per sex per dose:
4
Control animals:
not specified
Details on study design:
Duration of observation period following administration: 14 days
Statistics:
Dermal LD50 (and its fiducial range) estimated. Methods used are not detailed (probit analysis assumed).

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
12 126 mg/kg bw
Remarks on result:
other: 14.1 mL/kg bw adjusted for density of 0.86

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute dermal LD50 of m-xylene in the male New Zealand White rabbit was 12126 mg/kg.
Executive summary:

The acute dermal LD50 of m-xylene in the male New Zealand White rabbit was 14.1 mL/kg bodyweight, equivalent to 12126 mg/kg.