Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Acute toxicity of a homologous series of branched chain primary alcohols
Author:
Scala, R., Burtis E.
Year:
1973
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 34: 493-499

Materials and methods

Principles of method if other than guideline:
The principle of method was similar to guideline-study.
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
C11‑C14-iso, C13 rich (CAS RN 68526-86-3)

Test animals

Species:
rabbit
Strain:
other: Albino
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Details on dermal exposure:
The alcohol was applied full-strength to the closely clipped, intact abdominal skin. The exposed area was covered with an occlusive binding of dental damming for 24 hours. After the exposure, the binding was removed, and the remaining material, if any, was cleanded from the skin. The animals were housed individually with feed and water freely available. No mechanical restraints were used..
Duration of exposure:
24 hours
Doses:
0.1, 0.316, 1.00, and 3.16 ml/kg were administered volumetrically.
No. of animals per sex per dose:
4
Details on study design:
The animals were given a single application of the test substance to abraded abdominal skin under occlusive dressing for 24 hours. 
Observations for dermal irritation were made on a daily basis. Gross necropsies were performed at the end of the experiments.

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 2 600 mg/kg bw
Mortality:
No deaths were reported.

Applicant's summary and conclusion

Conclusions:
Scala and Burtis (1973) reported dermal LD50 values in rabbits of > 2600 mg/kg for alcohols C11‑C14-iso, C13 rich (CAS RN 68526-86-3).