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EC number: 701-005-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
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- Endpoint summary
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- Environmental data
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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- Toxicological Summary
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- Acute Toxicity
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- Specific investigations
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- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicity of a homologous series of branched chain primary alcohols
- Author:
- Scala R and Burtis E
- Year:
- 1 973
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 34: 493-499
Materials and methods
- Principles of method if other than guideline:
- The principle of method was similar to guideline-study.
- Test type:
- standard acute method
Test material
- Reference substance name:
- Alcohols, C11-14-iso-, C13-rich
- EC Number:
- 271-235-6
- EC Name:
- Alcohols, C11-14-iso-, C13-rich
- Cas Number:
- 68526-86-3
- Molecular formula:
- Unspecified
- IUPAC Name:
- Alcohols, C11-14-iso-, C13-rich
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Swiss mice, Wistar rats, and English Short hair guinea pigs, were group-housed by species during and after the exposures. Feed and water freely available during the post-exposure holding period.
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Details on inhalation exposure:
- The exposures were at athmospheres nearly saturated with vapors of the alcohol. The generators were fritted-disk glass bubblers containing a measured amount of alcohol through which all air entering the chamber was passed. No attempt was made to impact entrained droplets, and analytical determinations of chamber concentrations were note made. the nominal concentration was calculated from the net loss of alcohol from the bubblers and the total chamber airflow.
- Concentrations:
- 12 ppm (0.1 mg/l calculated)
- Details on study design:
- The basic design for the inhalation studies involved a single 6-hour exposure of groups of ten rats, mice and guinea pigs under dynamic conditions followed by a 24-hour holding period. Gross necropsies were performed on the animals that died and at the end of the holding period. The post-exposure observation period was 14 days. Histopathological examination was made of trachea, lung, liver, and kidney.
Results and discussion
- Mortality:
- No mortality was observed in any species providing an LC50 value greater than 12 ppm
- Clinical signs:
- other: Signs of systemic toxicity were not pronounced and consisted primarily of central nervous system depression.
Applicant's summary and conclusion
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