Reaction products of alkenes, C10-C14-(branched and linear), C12-rich, with hydrogen and carbon monoxide

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

publication

Title:

Acute toxicity of a homologous series of branched chain primary alcohols

Author:

Scala R and Burtis E

Year:

1973

Bibliographic source:

Am. Ind. Hyg. Assoc. J. 34: 493-499

Materials and methods

Principles of method if other than guideline:

The principle of method was similar to guideline-study.

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Alcohols, C11-14-iso-, C13-rich

EC Number:

271-235-6

EC Name:

Alcohols, C11-14-iso-, C13-rich

Cas Number:

68526-86-3

Molecular formula:

Unspecified

IUPAC Name:

Alcohols, C11-14-iso-, C13-rich

Test animals

Species:

rat

Strain:

Wistar

Sex:

not specified

Details on test animals or test system and environmental conditions:

Swiss mice, Wistar rats, and English Short hair guinea pigs, were group-housed by species during and after the exposures. Feed and water freely available during the post-exposure holding period.

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Details on inhalation exposure:

The exposures were at athmospheres nearly saturated with vapors of the alcohol. The generators were fritted-disk glass bubblers containing a measured amount of alcohol through which all air entering the chamber was passed. No attempt was made to impact entrained droplets, and analytical determinations of chamber concentrations were note made. the nominal concentration was calculated from the net loss of alcohol from the bubblers and the total chamber airflow.

Concentrations:

12 ppm (0.1 mg/l calculated)

Details on study design:

The basic design for the inhalation studies involved a single 6-hour exposure of groups of ten rats, mice and guinea pigs under dynamic conditions followed by a 24-hour holding period. Gross necropsies were performed on the animals that died and at the end of the holding period. The post-exposure observation period was 14 days. Histopathological examination was made of trachea, lung, liver, and kidney.

Results and discussion

Mortality:

No mortality was observed in any species providing an LC50 value greater than 12 ppm

Clinical signs:

other: Signs of systemic toxicity were not pronounced and consisted primarily of central nervous system depression.