Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Acute toxicity of a homologous series of branched chain primary alcohols
Author:
Scala R and Burtis E
Year:
1973
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 34: 493-499

Materials and methods

Principles of method if other than guideline:
The principle of method was similar to guideline-study.
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified
Details on test animals and environmental conditions:
Swiss mice, Wistar rats, and English Short hair guinea pigs, were group-housed by species during and after the exposures. Feed and water freely available during the post-exposure holding period.

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Details on inhalation exposure:
The exposures were at athmospheres nearly saturated with vapors of the alcohol. The generators were fritted-disk glass bubblers containing a measured amount of alcohol through which all air entering the chamber was passed. No attempt was made to impact entrained droplets, and analytical determinations of chamber concentrations were note made. the nominal concentration was calculated from the net loss of alcohol from the bubblers and the total chamber airflow.
Concentrations:
12 ppm (0.1 mg/l calculated)
Details on study design:
The basic design for the inhalation studies involved a single 6-hour exposure of groups of ten rats, mice and guinea pigs under dynamic conditions followed by a 24-hour holding period. Gross necropsies were performed on the animals that died and at the end of the holding period. The post-exposure observation period was 14 days. Histopathological examination was made of trachea, lung, liver, and kidney.

Results and discussion

Mortality:
No mortality was observed in any species providing an LC50 value greater than 12 ppm
Clinical signs:
other: Signs of systemic toxicity were not pronounced and consisted primarily of central nervous system depression.

Applicant's summary and conclusion