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Physical & Chemical properties

Partition coefficient

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Description of key information

Two experimental results (OECD Methods 107 and 117) and a QSAR estimation.

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
20 °C

Additional information

The determination of the log10Pow of DPGDB has been determined by two different experimental methods, OECD 107 and 117. The HPLC method (OECD 117) resulted in a log Pow value of 3.9, while a traditional shake-flask method (OECD 107) with analyses by HPLC produced a result of 4.3. The OECD 107 study was performed prior to it being known that DPGDB had surface active properties (Huntingdon Life Sciences study VCL0417); the guideline specifically states that it is unsuitable for surface active substances. An estimation of the log Pow was also conducted using QSAR (KOWWIN v.1.67) and resulted in a value of 3.88. Based upon the weight of evidence of similar results from the HPLC method and the QSAR (3.9 and 3.88) the log Pow value of 3.9 from the HPLC method has been utilized in the chemical safety report and the OECD 107 study was disregarded.