Registration Dossier
Registration Dossier
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EC number: 203-891-6 | CAS number: 111-64-8
Endpoint summary
Administrative data
Description of key information
LD 50 (oral, rat) : > 2000 mg/kg
LC50: (inhal., rat): Combined 0.63 mg/L/4h,
Key value for chemical safety assessment
Additional information
In an acute oral toxicity study according to OECD 423 male and female rats (3/dose) received doses of 500 and 2000 mg/kg (BASF 1998). No Mortality occurred. Signs of toxicity noted comprised impaired or poor general state, dyspnoea, apathy and staggering. The animals appeared normal within 3 days after application.
Five rats per sex and dose were exposed to 0.34, 0.68 and 1.10 mg/L (analytical) for 4h in an OECD 403 guideline study. Clinical signs of toxicity in animals comprised abdominal respiration, respiration sounds, eyelid closure, piloerection, squatting posture, apathy as well as poor general condition. Histopathological findings of the lung comprised moderate multifocal acute alveolar emphysema and edema, minimal multifocal acute necrosis of alveolar walls as well as severe diffuse total loss of bronchiolar respiratory epithelium. Combined LC50 value 0.63 mg/L/4h.
Justification for classification or non-classification
According to the results of the male LC50 the substance is classified as toxic by inhalation (acute inhal. Cat 2 and R23)
No classification suggested for acute dermal and oral toxicity as criteria of regulations 67/548/EC and 1272/2008/EC are not met.
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