Registration Dossier
Registration Dossier
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EC number: 203-891-6 | CAS number: 111-64-8
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound: With high probability acutely not harmful to fish.
Hydrolysis product: Octanoic acid: With high probability acutely not harmful to fish.
Hydrolysis product: HCl: Acutely toxic for fish (pH-dependent).
Key value for chemical safety assessment
Additional information
The acute toxicity on fish was studied according to OECD 203 with Danio rerio under static conditions (BASF AG, 1998). The test item was octanoyl chloride, which is expected to hydrolyse rapidly. The test item concentrations were analytically verified, but are based on the hydrolysis product octanoic acid. The test item concentrations initially agreed within the precision of the method with the expected concentrations, although the results of the two highest concentrations were inhomogeneous. Mortality occured only in the first hour in the two highest test solutions (215 and 464 mg/L, nominal). Therefore, the LC50 was calculated based on the initally measured concentrations: 96 -h LC50 = 157 mg/L.
No reliable data exist for the hydrolysis product octanoic acid, therefore a study with the analogue nonanoic acid (CAS 112 -05 -0) is presented. According to a study similar to OECD 203 with Pimephales promelas under flow-through conditions, the substance is also not harmful to fish (96 -h LC50 104 mg/L; Brooke et al., 1984).
The hydrolysis product hydrochloric acid (HCl) was tested in a semi-static acute toxicity test according to OECD 203 with Cyprinus carpio. The 96 -h LC50 was 4.92 mg/L (acid equivalent to pH 4.3; OECD 2002).
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