Registration Dossier
Registration Dossier
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EC number: 203-891-6 | CAS number: 111-64-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
In a pre-guideline LLNAGroups of mice are exposed daily, for 3 consecutive days, to various concentrations of the test chemical or to the relevant vehicle alone, on the dorsum of both ears. On day 5 following the initiation of exposure, mice are injected intravenously with [3H]thymidine and activity measured as a function of isotope incorporation in draining auricular lymph nodes (Kimber and Basketter, 1992). A stimulation index ≥ 3, together was observed in all concentration. Therfore nonanoylchlorid is regarded as sensitizing in the LLNA.
Due to the close sturctural similarity the same result is expected for octanoyl chloride.
Migrated from Short description of key information:
Nonanyl chloride is sensitizing in a valid pre-guideline LLNA. The same result is expected for octanoyl chloride due to close structural similarity.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
As the substance is toxic by inhalation no additional respiratory sensitization classification is warranted
Justification for classification or non-classification
Nonanyl chloride is sensitizing in a valid pre-guideline LLNA. The same result is expected for octanoyl chloride due to close structural similarity. As the substance is toxic by inhalation no additional respiratory sensitization classification is warranted.
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