Phenol, isopropylated, phosphate (3:1)

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

7 - 11 June 2005

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted by a recognised facility in compliance with GLP to a recent regulatory test guideline.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Water solubility:

0.367 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

Remarks on result:

other: pH not specified; assumed neutral as conducted in HPLC-grade reagent water.

Details on results:

The solubility of Reofos 35 in water was determined based upon the mean analytical results of samples analyzed on Days 2 and 3. Overall mean analytical results were 0.331 mg/L + 0.008 (RSD = 2.28%), 0.384 mg/L ± 0.020 (RSD = 5.17%) and 0.387 mg/L ± 0.005 (RSD = 1.22%) mg/L, respectively. The percent change in solubility between the Day 2 and Day 3 samples (using the overall mean values) was 16.0%. Thepercent change in solubility between the Day 3 and Day 4 samples was 0.781%. The water solubility of Reofos 35 was, therefore, determined to be 0.367 mg/L (SD = 0.030, RSD = 8.09%) calculated as the mean analytical result of all subsamples from the Day 2, 3 and 4 sampling intervals.

Solubility of Reofos 35 in HPLC-Grade Reagent Water at 20 °C Nominal Sample Sample Measured Mean % Change Concentration Identification Interval Concentration Std. Dev. Between (mg/L) (298C-145-) (Day) (mg/L) RSD Intervals 100 A-l 2 0.322 x =0.331   100 A-2 2 0.334 SD = 0.008 ~ 100 A-3 2 0.336 RSD = 2.28%   100 B-l 3 0.406 x =0.384   100 B-2 3 0.367 SD = 0.020 16.0 100 B-3 3 0.380 RSD = 5.17%   100 C-l 4 0.389 x =0.387   100 C-2 4 0.391 SD = 0.005 0.781 100 C-3 4 0.382 RSD = 1.22%       Mean = 0.367       Standard Deviation = 0.030         RSD = 8.09%

Conclusions:

Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The mean water solubility for the substance is 0.367 mg/l; the substance is considered slightly soluble.

Executive summary:

The water solubility was assessed using the flask shake method according to the OECD 105 guideline and samples analysed using GC/MS. Completed in triplicate and the mean result evaluated, the mean water solubility for the substance is 0.367 mg/l; the substance is considered slightly soluble.

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

7-11 June 2005

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted by a recognised facility in compliance with GLP to a recent regulatory test guideline.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Water solubility:

0.33 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

Remarks on result:

other: pH not specified; assumed neutral as conducted in HPLC-grade reagent water.

Details on results:

The solubility of Reofos 65 in water was determined based upon the mean analytical results of samples analyzed on Days 2 and 3. Overall mean analytical results were 0.355 mg/L ± 0.006 (RSD = 1.70%) and 0.304 mg/L + 0.007 (RSD = 2.38%), respectively. The percent change in solubility between the Day 2 and Day 3 samples (using the overall mean values) was 14.4%. The water solubility of Reofos 65 was, therefore, determined to be 0.330 mg/L (SD=0.028, RSD=8.55%) calculated as the mean analytical result of substances from Day 2 and 3 sampling intervals.

Solubility of Reofos 65 in HPLC-Grade Reagent Water at 20 °C Nominal Sample Sample Measured Mean % Change Concentration Identification Interval Concentration Std. Dev. Between (mg/L) (298C-145-) (Day) (mg/L) RSD Intervals 100 A-l 2 0.354 x =0.355   100 A-2 2 0.349 SD = 0.006 ~ 100 A-3 2 0.361 RSD = 1.70%   100 B-l 3 0.309 x =0.304   100 B-2 3 0.296 SD = 0.007 14.4 100 B-3 3 0.308 RSD = 2.38%       Mean = 0.330       Standard Deviation = 0.0280         RSD = 8.55%

Conclusions:

Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The mean water solubility for the substance is 0.330 mg/l; the substance is considered slightly soluble.

Executive summary:

The water solubility was assessed using the flask shake method according to the OECD 105 guideline and samples analysed using GC/MS. Completed in triplicate and the mean result evaluated, the mean water solubility for the substance is 0.330 mg/l; the substance is considered slightly soluble.

Description of key information

Water solubility

Key value for chemical safety assessment

Water solubility:

0.33 mg/L

at the temperature of:

20 °C

Additional information

Two GLP compliant studies are available on different runs of the product. These give the water solubility as a range of 0.330 to 0.367 mg/l at 20 °C