Phenol, isopropylated, phosphate (3:1)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

No information.

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Study is old data conducted to no recognised test guideline. The data are reported in a brief resume of the test and observations.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Test substance was administered orally as supplied by the sponsor to 5 male and 5 female rats. The method of dosing is not reported.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Phenol, isopropylated, phosphate (3:1)

EC Number:

273-066-3

EC Name:

Phenol, isopropylated, phosphate (3:1)

Cas Number:

68937-41-7

Molecular formula:

CXHYO4P X and Y are variable dependant on the molecular component.

IUPAC Name:

Phenol, isopropylated, phosphate (3:1)

Details on test material:

Samples : Colorless viscous liquid.
Markings : Krontrex 50
Lot No. 7-107.
No other information on the test material is detailed within the report.

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

Not reported.

Administration / exposure

Route of administration:

other: no data.

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

Single dose of 5000 mg/kg administered as received. No other data included.

Doses:

5000 mg/kg

No. of animals per sex per dose:

5 animals per sex per dose

Control animals:

no

Details on study design:

No data.

Statistics:

No data.

Results and discussion

Preliminary study:

No data.

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

95% CL:

>= 7 - <= 46

Mortality:

One animal on Day 1 and two animals on Day 2 died

Clinical signs:

other: No data.

Gross pathology:

No data.

Other findings:

None

Any other information on results incl. tables

Mortality data

Dose level mg/kg	No. rats dosed	deaths per day														Mortality after 14 days
		1	2	3	4	5	6	7	8	9	10	11	12	13	14
5000	10	1	2	0	0	0	0	0	0	0	0	0	0	0	0	3/10

Individual bodyweight data

Dose Level mg/kg	Animal No. & sex	Body weights (g)
		Initial	14 Days
5000	021M	275	280
	022M	264	320
	023M	357	397
	024M	273	---
	025M	268	325
	Average	287	311
5000	026F	186	215
	027F	180	---
	028F	210	235
	029F	205	---
	030F	190	220
	Average	194	223

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The substance demonstrated a 30% mortality rate and has been completed as a limit test at 5000 mg/kg The LD50 is considered to be >5000 mg/kg.

Executive summary:

The test sample was dosed orally to 5 male and 5 female rats at a dose of 5000 mg/kg. Assessed over a 14 day period, 1 male and 2 female deaths occured and the study was completed as a limit test. The LD50 is considered >5000 mg/kg.

No classification is applicable on the basis of the results.