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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
No information.
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Study is old data conducted to no recognised test guideline. The data are reported in a brief resume of the test and observations.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Test substance was administered orally as supplied by the sponsor to 5 male and 5 female rats. The method of dosing is not reported.

GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenol, isopropylated, phosphate (3:1)
EC Number:
273-066-3
EC Name:
Phenol, isopropylated, phosphate (3:1)
Cas Number:
68937-41-7
Molecular formula:
CXHYO4P X and Y are variable dependant on the molecular component.
IUPAC Name:
Phenol, isopropylated, phosphate (3:1)
Details on test material:
Samples : Colorless viscous liquid.
Markings : Krontrex 50
Lot No. 7-107.
No other information on the test material is detailed within the report.

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
Not reported.

Administration / exposure

Route of administration:
other: no data.
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
Single dose of 5000 mg/kg administered as received. No other data included.
Doses:
5000 mg/kg
No. of animals per sex per dose:
5 animals per sex per dose
Control animals:
no
Details on study design:
No data.
Statistics:
No data.

Results and discussion

Preliminary study:
No data.
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
95% CL:
>= 7 - <= 46
Mortality:
One animal on Day 1 and two animals on Day 2 died
Clinical signs:
other: No data.
Gross pathology:
No data.
Other findings:
None

Any other information on results incl. tables

Mortality data

Dose level mg/kg

No. rats dosed

deaths per day

Mortality after 14 days

1

2

3

4

5

6

7

8

9

10

11

12

13

14

5000

10

1

2

0

0

0

0

0

0

0

0

0

0

0

0

3/10

Individual bodyweight data

Dose Level mg/kg

Animal No. & sex

Body weights (g)

Initial

14 Days

5000

021M

275

280

 

022M

264

320

 

023M

357

397

 

024M

273

---

 

025M

268

325

 

Average

287

311

5000

026F

186

215

 

027F

180

---

 

028F

210

235

 

029F

205

---

 

030F

190

220

 

Average

194

223

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance demonstrated a 30% mortality rate and has been completed as a limit test at 5000 mg/kg The LD50 is considered to be >5000 mg/kg.

Executive summary:

The test sample was dosed orally to 5 male and 5 female rats at a dose of 5000 mg/kg. Assessed over a 14 day period, 1 male and 2 female deaths occured and the study was completed as a limit test. The LD50 is considered >5000 mg/kg.

No classification is applicable on the basis of the results.