Registration Dossier
Registration Dossier
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EC number: 201-696-0 | CAS number: 86-74-8
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Acute / short-term exposure
In acute toxicity studies, carbazole has been shown to be of very low toxicity. From available studies, reliable short-term dose response relations cannot be deduced. DN(M)EL's are not to be derived because of the low acute toxicity of carbazole (see ECHA guidance on information requirements and chemical safety assessment - Chapter R.8).
Long-term exposure
No comprehensive repeated dose toxicity data are available.
In the carcinogenicity study (Section 7.7, Tsuda 1982; oral administration in diet), no toxicological endpoints except carcinogenicity are reported. Thus no dose descriptor for repeated dose toxicity is available.
In the developmental toxicity study (Section 7.8.2, Dutson 1997; dermal administration), exposure time is only 20 days. Administration is via dermal route with test substance dissolved in DMSO. Exposed animals are pregnant females and important toxicological endpoints (hematological, clinical parameters, organ weights) have not been examined. Deviations from standard repeated dose toxicity guidelines are assessed to be too extensive as to provide for a reliable dose descriptor for the endpoint repeated dose toxicity.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Acute / short-term exposure
In acute toxicity studies, carbazole has been shown to be of very low toxicity. From available studies, reliable short-term dose response relations cannot be deduced. DN(M)EL's are not to be derived because of the low acute toxicity of carbazole (see ECHA guidance on information requirements and chemical safety assessment - Chapter R.8).
Long-term exposure
No suited repeated dose toxicity data or dose descriptors are available.
In the carcinogenicity study (Section 7.7, Tsuda 1982; oral administration in diet), no toxicological endpoints except carcinogenicity are reported. Thus no dose descriptor for repeated dose toxicity is available.
In the developmental toxicity study (Section 7.8.2, Dutson 1997; dermal administration), exposure time is only 20 days. Administration is via dermal route with test substance dissolved in DMSO. Exposed animals are pregnant females and important toxicological endpoints (hematological, clinical parameters, organ weights) have not been examined. Deviations from standard repeated dose toxicity guidelines are assessed to be too extensive as to provide for a reliable dose descriptor for the endpoint repeated dose toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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