Registration Dossier
Registration Dossier
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EC number: 201-696-0 | CAS number: 86-74-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
No data have been located concerning toxicity to reproduction (fertility) (Endpoint not required under REACH).
Effects on developmental toxicity
Description of key information
In a dermal developmental toxicity study (Dutson 1997), carbazole did not induce any maternal or developmental toxic effects up to the higest concentration tested (250 mg/kg bw).
Additional information
One study on developmental toxicity / teratogenicity of carbazole has been located (Dutson et al. 1997).
The method used does not follow specific actual test guidelines. Carbazole was administered dermally to pregnant rats during gestation day 0 through 20 using three graduated doses, and dams were allowed to deliver. Pups were observed until lactation day 4 and all animals (pups and dams) were then sacrificed. Litters were examined externally for gross abnormalities and for weight development and mortality. Dams were inspected for uterine content.
In this dermal developmental toxicity study, carbazole did not induce any maternal or developmental toxic effects up to the highest concentration tested (250 mg/kg bw).
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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