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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 429-240-8 | CAS number: 212652-59-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: Assessment
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Objective of study:
- other: Assessment of toxicokinetic behaviour
- GLP compliance:
- no
- Conclusions:
- With a water solubility of >200 g/l and a log Pow of minus 4.0 c, the substance shows a low bio-availability. This statement is also confirmed by results of acute testing. Also in the 28 days-subacute test we find by obvious leak of toxic behaviour pure hints on gastrointestinal resorption
followed by distribution. An inhalative exposition may be fully excluded based on the particle distribution of final sales form. The notified substance is a powder without significant respirable fraction as the potential dust is treated during manufacturing in closed system with dedusting compound and therefore a dust-free sales form is introduced into the market. - Executive summary:
FAT 40574/B has been tested for acute toxicity by oral and dermal application, for subacute toxicity by oral application and for irritant effects on skin and eyes and contact sensitization. Tests for mutagenicity have been performed in vitro without direct relevance for toxicokinetics. In the test for acute oral and dermal toxicity in rats FAT 40574/B has been applied at a dose level of 2000 mg/kg body weight. In a 28-days study FAT 40574/B was applied to rats by gavage at dose levels of 0, 50, 200 and 1000 mg/kg body weight daily. This resulted in no severe toxic effects. [NOAEL: 200 mg/kg/body weight]. With a water solubility of >200 g/l and a log Pow of -4.0, the substance shows a low bio-availability. This statement is also confirmed by results of acute testing. Also in the 28 days-subacute test we find by obvious leak of toxic behaviour pure hints on gastrointestinal resorption followed by distribution. An inhalative exposition may be fully excluded based on the particle distribution of final sales form. The notified substance is a powder without significant respirable fraction as the potential dust is treated during manufacturing in closed system with antidusting compound and therefore a dust-free sales form is introduced into the market.
Reference
FAT 40574/B has been tested for acute toxicity by oral and dermal application, for subacute toxicity by oral application and for irritant effects on skin and eyes and contact sensitization. Tests for mutagenicity have been performed in vitro without direct relevance for toxicokinetics. In the test for acute oral and dermal toxicity in rats FAT 40574/B has been applied at a dose level of 2000 mg/kg body weight. In a 28-days study FAT 40574/B was applied to rats by gavage at dose levels of 0, 50, 200 and 1000 mg/kg body weight daily. This resulted in no severe toxic effects. [NOAEL: 200 mg/Kg/body weight]. With a water solubility of >200 g/l and a log Pow of -4.0, the substance shows a low bio-availability. This statement is also confirmed by results of acute testing. Also in the 28 days-subacute test we find by obvious leak of toxic behaviour pure hints on gastrointestinal resorption followed by distribution. An inhalative exposition may be fully excluded based on the particle distribution of final sales form. The notified substance is a powder without significant respirable fraction as the potential dust is treated during manufacturing in closed system with antidusting compound and therefore a dust-free sales form is introduced into the market.
Description of key information
FAT 40574/B has been tested for acute toxicity by oral and dermal application, for subacute toxicity by oral application and for irritant effects on skin and eyes and contact sensitization. Tests for mutagenicity have been performed in vitro without direct relevance for toxicokinetics. In the test for acute oral and dermal toxicity in rats FAT 40574/B has been applied at a dose level of 2000 mg/kg body weight. In a 28-days study FAT 40574/B was applied to rats by gavage at dose levels of 0, 50, 200 and 1000 mg/kg body weight daily. This resulted in no severe toxic effects. [NOAEL: 200 mg/kg/body weight]. With a water solubility of >200 g/l and a log Pow of -4.0, the substance shows a low bio-availability. This statement is also confirmed by results of acute testing. Also in the 28 days-subacute test we find by obvious leak of toxic behaviour pure hints on gastrointestinal resorption followed by distribution. An inhalative exposition may be fully excluded based on the particle distribution of final sales form. The notified substance is a powder without significant respirable fraction as the potential dust is treated during manufacturing in closed system with antidusting compound and therefore a dust-free sales form is introduced into the market.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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