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Physical & Chemical properties

Partition coefficient

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Description of key information

The study was considered to be not technically feasible according to the information provided in the Walker & White, 2010 study due to rapid hydrolyses of the test subtsance, as demonstrated in a water solubility study.

Key value for chemical safety assessment

Additional information

In accordance with Annex XI section 2 of the Regulation EC 1907/2006, testing for a specific endpoint may be omitted, if it is technically not possible to conduct the study as a consequence of the properties of the substance.

The following statement was included in a physico-chemical properties study by Walker & White (2010) concerning the feasibility of a partition coefficient study on the test substance:

"No determination was performed according to Methods 107 and/or 117 of the OECD Guidelines for Testing of Chemicals, 27 July 1995 and 13 April 2004 respectively, for the following reasons:

• During preliminary investigations for the water solubility test, the test item was concluded to hydrolyse fully within 3 minutes of contact with water. Substances which hydrolyse rapidly in contact with water are not suitable for determination using Methods 107 and/or 117.

• Estimation using the ratio of the solubility of the test item in n-octanol and water would also be unreliable due to the rapid hydrolysis of the test item in the water."